119450-11-2Relevant academic research and scientific papers
Generation of the Methoxycarbonyl Radical by Visible-Light Photoredox Catalysis and Its Conjugate Addition with Electron-Deficient Olefins
Slutskyy, Yuriy,Overman, Larry E.
supporting information, p. 2564 - 2567 (2016/07/06)
Visible-light photoredox-catalyzed fragmentation of methyl N-phthalimidoyl oxalate allows the direct construction of a 1,4-dicarbonyl structural motif by a conjugate addition of the methoxycarbonyl radical to reactive Michael acceptors. The regioselectivity of the addition of this alkoxyacyl radical species to electron-deficient olefins is heavily influenced by the electronic nature of the acceptor, behavior similar to that exhibited by nucleophilic alkyl radicals.
The non-metathetic role of Grubbs' carbene complexes: From hydrogen-free reduction of α,β-unsaturated alkenes to solid-supported sequential cross-metathesis/reduction
Poeylaut-Palena, Andres A.,Testero, Sebastian A.,Mata, Ernesto G.
, p. 1565 - 1567 (2011/03/20)
An efficient and high-yielding "hydrogen-free" reduction of α,β-unsaturated alkenes was carried out employing Grubbs' catalyst in a non-metathetic role and Et3SiH. Conditions were optimized under microwave irradiation. Application to the solid-phase organic synthesis allows a facile construction of sp3-sp3 carbon bonds through a sequential cross metathesis/olefin reduction.
Diaminoterephthalates: Scaffolds for combinatorial chemistry
Pflantz, Rebekka,Christoffers, Jens
experimental part, p. 2200 - 2209 (2009/09/25)
2,5-Diaminoterephthalates that possess four points of diversification are introduced as new scaffolds for combinatorial chemistry. A straightforward synthesis of an orthogonally protected platform compound was developed. This platform was transformed by s
Synthesis of 1,4-Dicarbonyl Compounds via the Conjugate Addition of a Masked Activated Ester, ROCH(CN)2
Kubota, Yasufumi,Nemoto, Hisao,Yamamoto, Yoshinori
, p. 7195 - 7196 (2007/10/02)
A new acyl anion equivalent for the preparation of masked activated esters, the protected hydroxymalonitrile 1, readily undergoes conjugate addition to α,β-unsaturated carbonyl derivatives 2 to give the masked 1,4-dicarbonyl compounds 3 in good to high yi
