600-23-7

Basic information

• Product Name: Ethanedioic acid, MonoMethyl ester
• Synonyms: Ethanedioic acid, MonoMethyl ester;methyl hydrogen oxalate
• CAS NO: 600-23-7
• Molecular Formula: C₃H₄O₄
• Molecular Weight: 104.06146
• EINECS: -0
• Mol File: 600-23-7.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 192.9±23.0 °C(Predicted)
• Appearance: /
• Density: 1.366±0.06 g/cm3(Predicted)
• PKA: 1.45±0.54(Predicted)
• CAS DataBase Reference: Ethanedioic acid, MonoMethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanedioic acid, MonoMethyl ester(600-23-7)
• EPA Substance Registry System: Ethanedioic acid, MonoMethyl ester(600-23-7)

Safety Data

• Hazardous Substances Data: 600-23-7(Hazardous Substances Data)

Usage

General Description

Ethanedioic acid, monomethyl ester, also known as methyl oxalate, is a colorless liquid with a fruity odor. It is a chemical compound commonly used as a solvent and in the production of pharmaceuticals and synthetic resins. It is also used as a precursor for various organic synthesis reactions. Ethanedioic acid, monomethyl ester is considered toxic if ingested, inhaled, or absorbed through the skin, and can cause irritation and damage to the respiratory system, skin, and eyes. It is important to handle this chemical with care and to use appropriate personal protective equipment when working with it.

Upstream product

• 109-86-4 2-methoxy-ethanol 
• 213967-57-8 1,4-Dioxane-2,3,5,6-tetrone 
• 67-56-1 methanol 
• 21113-74-6 dimethyl 2-methoxy-5-phenylfuran-3,4-dicarboxylate 
• 115852-14-7 methyl 2-methoxy-5-phenyl-furan-4-carboxylate 
• 115852-15-8 4-acetyl-2-methoxy-5-phenylfuran 
• 144-62-7 oxalic acid 
• 56-23-5 tetrachloromethane 
• 18083-81-3 methyl 9-fluoreneglyoxylate 

Downstream Products

• 144-62-7 oxalic acid 
• 39848-02-7 2-hydroxy-4-(4-methoxyphenyl)-4-oxo-but-2-enoic acid methyl ester 
• 93-58-3 benzoic acid methyl ester 
• 921930-30-5 C₁₆H₉BrClF₃N₂O₄ 
• 1132841-11-2 C₇H₁₀N₂O₃ 
• 107-31-3 Methyl formate 
• 1064013-85-9 hydroxymethoxycarbene 
• 81657-50-3 1,3-bis-(4-chlorophenyl)-imidazolidine-trione 
• 614-27-7 methyl 3-oxo-3-phenylpropionate 
• 120-75-2 2-Methylbenzothiazole 
• 87802-07-1 benzothiazole-2-carboxylic acid methyl ester 
• 6164-79-0 methyl pyrazine-2-carboxylate 
• 57409-49-1 methyl 2,4-dioxo-6-phenylhex-5-enoate 
• 119450-11-2 benzyl methyl succinate 

Relevant articles and documents

A metal-free strategy for the cross-dehydrogenative coupling of 1,3-dicarbonyl compounds with 2-methoxyethanol

Here, we report a metal-free approach for the construction of methylene-bridged bis-1,3-dicarbonyl compounds via cross-dehydrogenative coupling of 1,3-dicarbonyl compounds with 2-methoxyethanol. In addition, we have extended this methodology to synthesize tetra-substituted pyridine derivatives using 1,3-dicarbonyl, 2-methoxyethanol and NH4OAc in one step. The key advantages include accepting a wide range of substrates, utilizing O2 as the sole oxidant, and synthesizing biologically active compounds such as 1,4-dihydropyridine and pyrazole. This journal is

Miniolins A-C, novel isomeric furanones induced by epigenetic manipulation of Penicillium minioluteum

Cultivation of Penicillium minioluteum with azacitidine, a DNA methyltransferase inhibitor, led to the isolation of a novel type of aspertetronin dimer, named miniolins A-C (1-3), along with their precursor aspertetronin A (4). The structures of 1-3 were elucidated by extensive spectroscopic methods, and the absolute configurations were assigned by the chiral HPLC analysis of chemical degradation products and electronic circular dichroism associated with the TDDFT computational method (CAM-B3LYP/TZVP). The miniolins showed moderate cytotoxic activity against Hela cell lines. This journal is

Photosensitized Oxidation of Furans. Part 14. Nature of Intermediates in Thermal Rearrangement of Some endo-Peroxides of 2-Alkoxyfurans: New Rearrangement Pathway of Furan endo-Peroxides

2-Methoxy-5-phenylfurans (1a-c) substituted at C-4 with electron-withdrawing groups, by dye-sensitized photo-oxygenation in non-participating solvents, give the endo-peroxides (3a-c) which by thermal rearrangement partly yield the 3H-1,2-dioxoles (14a-c).The latter, which are the first examples of this ring system, are thermally very unstable.Their formation can be deduced only from the products obtained by thermal rearragement which are structurally related with the thermal rearrangement products of 3H-1,2,4-dioxazoles (10).The behavior of the furans (1a-c) contrasts with that of the 2-methoxy-5-phenylfurans unsubstituted at C-4 which under the same conditions give carbonyl oxides.