1194506-54-1

Basic information

• Product Name: 6,6-dimethyl-1-(4-methyl-benzyl)-1,6-dihydro-1,3,5-triazine-2,4-diamine hydrochloride
• CAS NO: 1194506-54-1
• Molecular Weight: 281.788
• Mol File: 1194506-54-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 6,6-dimethyl-1-(4-methyl-benzyl)-1,6-dihydro-1,3,5-triazine-2,4-diamine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 6,6-dimethyl-1-(4-methyl-benzyl)-1,6-dihydro-1,3,5-triazine-2,4-diamine hydrochloride(1194506-54-1)
• EPA Substance Registry System: 6,6-dimethyl-1-(4-methyl-benzyl)-1,6-dihydro-1,3,5-triazine-2,4-diamine hydrochloride(1194506-54-1)

Safety Data

• Hazardous Substances Data: 1194506-54-1(Hazardous Substances Data)

Upstream product

• 108484-54-4 N-1-(4-methyl)benzylbiguanide hydrochloride 
• 67-64-1 acetone 

Relevant articles and documents

Synthesis and in vitro evaluation of 2,4-diamino-1,3,5-triazine derivatives as neuronal voltage-gated sodium channel blockers

Neuronal sodium channels blockers interfere with ion flux and have been used for managing neuropathic pain, epilepsy, and cerebral ischemic disorders. In the current study, four groups of 2,4-diamino-1,3,5-triazine derivatives were synthesized and investigated for their neuronal sodium channels binding activity. 5-Aryl-1,3,5-triazaspiro[5.5]undeca-1,3-diene-2,4-diamines (4a-4j) were found to have the best neuronal sodium binding activity among the four groups of triazines evaluated. Derivatives 4a-4j blocked the sodium channels with IC50 values ranged from 4.0 to 14.7 μM. The result from this study showed that analogues of 2,4-diamino-1,3,5-triazines could be used as leads for the discovery of neuronal sodium channels blockers for managing central nervous system related disorders.