1194510-06-9Relevant articles and documents
Asymmetric synthesis of 3- or 4-alkyl or arylbenzo[c]azepines
Dumoulin, David,Lebrun, Stephane,Couture, Axel,Deniau, Eric,Grandclaudon, Pierre
, p. 1903 - 1911 (2009)
Two flexible routes for the stereoselective synthesis of a variety of 3- or 4-alkylated or arylated tetrahydrobenzazepines have been developed. The key steps are the highly diastereoselective metallation/alkylation reaction and 1,2-addition processes applied to stereopure SAMP hydrazones combined with a cyclomethylenation reaction.