119458-46-7Relevant articles and documents
N-Alkylation of Substituted Pyrazoles and Pyrazolopyrimidines with Dimethylformamide Diethyl Acetal or Triethyl Orthoformate
Bulychev, Yu. N.,Preobrazhenskaya, M. N.,Chernyshev, A. I.,Esipov, S. E.
, p. 751 - 755 (2007/10/02)
The N-alkylation of some substituted pyrazoles and pyrazolopyrimidines with dimethylformamide diethyl acetal or triethyl orthoformate has been examined.Dimethylformamide diethyl acetal is more effective as an alkylating agent than triethyl orthoformate.Alkylation of 3-methoxycarbonylpyrazole gives a mixture of N-1- and N-2-ethyl derivatives.Alkylation of pyrazolopyrimidines takes place at the 1-position of the pyrazole ring only.In the case of thio-derivatives of pyrazolopyrimidines, S-alkylation occurs in addition to N-alkylation.