15366-34-4

Basic information

• Product Name: METHYL 1H-PYRAZOLE-3-CARBOXYLATE
• Synonyms: TIMTEC-BB SBB000006;METHYL 1H-PYRAZOLE-3-CARBOXYLATE;1H-PYRAZOLE-3-CARBOXYLIC ACID METHYL ESTER;Albb-003661;methyl 1H-pyrazole-;methyl 1H-pyrazole-3-carboxylate(SALTDATA: FREE);Methyl Pyrazole-3-carboxylate;4-Pyrazolecarboxylic Acid Methyl Ester
• CAS NO: 15366-34-4
• Molecular Formula: C₅H₆N₂O₂
• Molecular Weight: 126.11334
• EINECS: 1308068-626-2
• Product Categories: pharmacetical;Aromatics;Heterocycles;Intermediates
• Mol File: 15366-34-4.mol
• Article Data: 22

Chemical Properties

• Melting Point: 141-142℃
• Boiling Point: 271℃
• Flash Point: 118℃
• Appearance: /
• Density: 1.275
• Vapor Pressure: 0.00657mmHg at 25°C
• Refractive Index: 1.53
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: Soluble in methanol.
• PKA: 11.04±0.10(Predicted)
• CAS DataBase Reference: METHYL 1H-PYRAZOLE-3-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 1H-PYRAZOLE-3-CARBOXYLATE(15366-34-4)
• EPA Substance Registry System: METHYL 1H-PYRAZOLE-3-CARBOXYLATE(15366-34-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 22
• HazardClass: IRRITANT
• Hazardous Substances Data: 15366-34-4(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 15366-34-4 differently. You can refer to the following data:
1. The methyl ester derivative of 4-Pyrazolecarboxylic Acid (P842550), Methyl Pyrazole-3-carboxylate can be used in the preparation of androgen receptor (AR) antagonists as well as pyrazole nucleosides.
2. The methyl ester derivative of 4-Pyrazolecarboxylic Acid (P842550) used in the preparation of androgen receptor (AR) antagonists as well as pyrazole nucleosides.

InChI:InChI=1/C5H6N2O2/c1-9-5(8)4-2-3-6-7-4/h2-3H,1H3,(H,6,7)

Upstream product

• 186581-53-3 diazomethane 
• 922-67-8 propynoic acid methyl ester 
• 5334-40-7 4-nitro-1H-pyrazole-3-carboxylic acid 
• 1621-91-6 1H-pyrazole-3-carboxylic acid 
• 67-56-1 methanol 
• 76240-19-2 4-ethoxy-2-oxobut-3-enoic acid ethyl ester 
• 135641-58-6 4-chloro-3,3-bis(methoxycarbonyl)-4,5-dihydro-3H-pyrazole 
• 141178-40-7 methyl 2-diazo-3-hydroxybutanoate 
• 24762-04-7 2-Diazo-3-oxo-butyric acid methyl ester 
• 158615-33-9 4-Cyano-3-(toluene-4-sulfonyloxy)-4,5-dihydro-3H-[1,2,3]triazole-4-carboxylic acid methyl ester 
• 103582-19-0 3-acetoxy-3-methoxycarbonyl-1-pyrazoline 
• 135641-60-0 3,3-bis(methoxycarbonyl)-3H-pyrazole 
• 762-42-5 dimethyl acetylenedicarboxylate 
• 87879-93-4 4-diazo-1,1,1,2,2-pentafluoro-3-pentafluoroethyl-3-trifluoromethylbutane 

Downstream Products

• 138786-89-7 1-((2R,3R,4R,5R)-3,4-Bis-benzoyloxy-5-benzoyloxymethyl-tetrahydro-furan-2-yl)-1H-pyrazole-3-carboxylic acid methyl ester 
• 122818-18-2 methyl 1-vinyl-1H-pyrazole-5-carboxylate 
• 122609-01-2 1-Vinyl-1H-pyrazole-3-carboxylic acid methyl ester 
• 135641-78-0 1-ethoxycarbonyl-3-methoxycarbonyl-1H-pyrazole 
• 119458-46-7 2-ethyl-3-methoxycarbonylpyrazole 
• 89943-27-1 N-1-ethyl-3-methoxycarbonylpyrazole 
• 23585-49-1 (1H-pyrazol-3-yl)methanol 
• 85605-94-3 4-fluoro-1H-pyrazole-3-carboxylic acid methyl ester 
• 150017-55-3 1-Aminopyrazol-5-carbonsaeure-methylester 
• 150017-47-3 1-Aminopyrazol-3-carbonsaeure-methylester 
• 26275-64-9 1H-pyrazole-3-carbohydrazide 
• 922516-36-7 tert-butyl 4-[3-(methoxycarbonyl)pyrazol-1-yl]piperidine-1-carboxylate 
• 922516-37-8 tert-butyl 4-(5-(methoxycarbonyl)-1H-pyrazol-1-yl)piperidine-1-carboxylate 
• 150017-62-2 1-(Ethoxymethylenamino)pyrazol-3-carbonsaeure-methylester 

Relevant articles and documents

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COMPOUNDS WITH COPPER- OR ZINC-ACTIVATED TOXICITY AGAINST MICROBIAL INFECTION

Heterocyclic compounds with a novel pyrazole thioamide-based NNSN structural motif, having highly effective zinc- or copper-activated toxicity against microbial infections at micromolar or nanomolar minimum inhibitory concentrations (MIC), and methods of making and using same.

Optimization and biological evaluation of 2-aminobenzothiazole derivatives as Aurora B kinase inhibitors

A strong relationship between abnormal functions of Aurora kinases and tumorigenesis has been reported for decades. Consequently, Aurora kinases serve as potential targets for anticancer agents. Here, we identified aminobenzothiazole derivatives as novel inhibitors of Aurora B kinase through bioisosteric replacement of the previous inhibitors, aminobenzoxazole derivatives. Most of the urea-linked aminobenzothiazole derivatives showed potent and selective inhibitory activity against Aurora B kinase over Aurora A kinase. Molecular modeling indicated that compound 15g bound well to the active site of Aurora B kinase and formed the essential hydrogen bonds. The potent compounds, 15g and 15k, were selected, and their biological effects were evaluated using HeLa cell lines. It was found that these compounds inhibited the phosphorylation of histone H3 at Ser10 and induced G2/M cell cycle arrest. We suggest that the reported compounds have the potential to be further developed as anticancer therapeutics.

4,7-DIHYDRO-PYRAZOLO[1,5-a]PYRAZIN-6-YLAMINE DERIVATIVES USEFUL AS INHIBITORS OF BETA-SECRETASE (BACE)

The present invention relates to novel 4,7-dihydro-pyrazolo[1,5-a]pyrazin-6-yl-amine derivatives as inhibitors of beta-secretase, also known as beta-site amyloid cleaving enzyme, BACE, BACE1, Asp2, or memapsin2. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention and treatment of disorders in which beta-secretase is involved, such as Alzheimer's disease (AD), mild cognitive impairment, senility, dementia, dementia with Lewy bodies, Down's syndrome, dementia associated with stroke, dementia associated with Parkinson's disease or dementia associated with beta-amyloid.