119472-66-1

Upstream product

• 589-92-4 1-methylcyclohexan-4-one 
• 1025373-45-8 trifluoromethanesulfonic acid anhydride 
• 37595-74-7 N,N-phenylbistrifluoromethane-sulfonimide 
• 358-23-6 trifluoromethylsulfonic anhydride 
• 108-94-1 cyclohexanone 

Downstream Products

• 119472-70-7 2-[2-(4-Methyl-cyclohex-1-enyl)-allyl]-malonic acid dimethyl ester 
• 119472-71-8 2-[(E)-2-(4-Methyl-cyclohex-1-enyl)-dec-2-enyl]-malonic acid dimethyl ester 
• 119472-72-9 2-[(Z)-2-(4-Methyl-cyclohex-1-enyl)-dec-2-enyl]-malonic acid dimethyl ester 
• 865869-26-7 4,4,5,5-tetramethyl-2-(4-methylcyclohex-1-en-1-yl)-1,3,2-dioxaborolane 
• 104258-28-8 1-ethynyl-4-methylcyclohex-1-ene 
• 1449115-34-7 4-(4-methylcyclohex-1-en-1-yl)-1-tosyl-1H-1,2,3-triazole 
• 1449115-04-1 6-methyl-1-tosyl-4,5,6,7-tetrahydro-1H-indole 
• 1383385-13-4 C₂₈H₃₆N₂O₃S 
• 1383385-12-3 C₂₆H₃₄N₂O₂S 
• 1383385-11-2 C₃₁H₄₂N₂O₄S 
• 1383383-33-2 5-(3-acetylamino-phenyl)-3-[1-ethyl-5-(4-methyl-cyclohexyl)-1,2,3,6-tetrahydro-pyridin-4-yl]-thiophene-2-carboxylic acid 
• 1383383-30-9 5-(3-amino-3-methyl-but-1-ynyl)-3-(1-ethyl-5-(4-methyl-cyclohexyl)-1,2,3,6-tetrahydro-pyridin-4-yl)-thiophene-2-carboxylic acid 
• 1383385-09-8 C₂₅H₃₆N₂O₂S 
• 1383383-27-4 5-(4-acetylamino-phenyl)-3-[1-ethyl-5-(4-methyl-cyclohexyl)-1,2,3,6-tetrahydro-pyridin-4-yl]-thiophene-2-carboxylic acid 

Relevant academic research and scientific papers

Nickel-Catalyzed Decarboxylative Alkenylation of Anhydrides with Vinyl Triflates or Halides

Decarboxylative cross-coupling of aliphatic acid anhydrides with vinyl triflates or halides was accomplished via nickel catalysis. This methodology works well with a broad array of substrates and features abundant functional group tolerance. Notably, our approach addresses the issue of safe and environmental installation of methyl or ethyl group into molecular scaffolds. The method possesses high chemoselectivity toward alkyl groups when aliphatic/aromatic mixed anhydrides are involved. Furthermore, diverse ketones could be modified with our strategy.

Ene-hydrazide from enol triflate for the regioselective Fischer indole synthesis

Ene-hydrazide prepared from enol triflate undergoes a Fischer indolization reaction to give the corresponding indole with complete regioselectivity. The starting enol triflate is readily accessed in regiochemically defined form from the ketone precursor via various well-established methods. This new protocol was successfully applied to the synthesis of desbromoarborescidine A, a natural β-carboline alkaloid, difficult to prepare with conventional Fischer indole synthesis.

INHIBITORS OF VIRAL REPLICATION, THEIR PROCESS OF PREPARATION AND THEIR THERAPEUTICAL USES

The present invention relates to compounds of formula (1) as claimed in claim 1, their use in the treatment or the prevention of viral disorders, including HIV. (Formula I)

INHIBITORS OF HEPATITIS C VIRUS POLYMERASE

The present invention provides, among other things, compounds represented by the general Formula (I) and pharmaceutically acceptable salts thereof, wherein X, Y, R1A, R1B, R2, and R3 are as defined in classes and subclasses herein and compositions (e.g., pharmaceutical compositions) comprising such compounds, which compounds are useful as inhibitors of hepatitis C virus polymerase, and thus are useful, for example, as medicaments for the treatment of HCV infection.

QUINAZOLINONE DERIVATIVES AS VIRAL POLYMERASE INHIBITORS

Compounds of formula I: (I) wherein X, R2, R3, R5 and R6 are defined herein, are useful as inhibitors of the hepatitis C virus NS5B polymerase.

SUBSTITUTED FUROPYRIMIDINES AND USE THEREOF

The present application relates to novel substituted furopyrimidine derivatives, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, especially for the treatment and/or prophylaxis of cardiovascular diseases.

4-CARBOX PYRAZOLE DERIVATES USEFUL AS ANTI-VIRAL AGENTS

Novel antiviral compounds of Formula (I) : wherein: A represents hydroxy; R1 represents aryl, heteroaryl bonded through a ring carbon atom, or heterocyclyl bonded through a ring carbon atom, C1-6alkyl or -C5-9cycloalkyl, each of which may be optionally su