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1194732-22-3

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1194732-22-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1194732-22-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,9,4,7,3 and 2 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1194732-22:
(9*1)+(8*1)+(7*9)+(6*4)+(5*7)+(4*3)+(3*2)+(2*2)+(1*2)=163
163 % 10 = 3
So 1194732-22-3 is a valid CAS Registry Number.

1194732-22-3Relevant articles and documents

Strategies to lower the Pgp efflux liability in a series of potent indole azetidine MCHR1 antagonists

Lu, Kai,Jiang, Yu,Chen, Bin,Eldemenky, Eman M.,Ma, Gil,Packiarajan, Mathivanan,Chandrasena, Gamini,White, Andrew D.,Jones, Kenneth A.,Li, Boshan,Hong, Sang-Phyo

supporting information; experimental part, p. 5310 - 5314 (2011/10/03)

A series of potent indolyl azetidine rMCHR1 antagonists were found to show poor CNS penetration due to Pgp efflux. We envisioned a strategy which included: lowering basicity; changing the conformational flexibility motif; and removal of a hydrogen bond donor, in an attempt to optimize this property while maintaining target receptor efficacy. This work resulted in mitigation of Pgp efflux, and led us to identify 1-dihydroindolyl azetidine derivatives with CNS penetration and excellent rMCHR1 binding affinity.

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