1194731-94-6

Basic information

• Product Name: 4-benzyloxy-1-{1-[1-(2-fluoro-ethyl)-azetidin-3-yl]-2,3-dihydro-1H-indol-5-yl}-1H-pyridin-2-one
• CAS NO: 1194731-94-6
• Molecular Weight: 419.499
• Mol File: 1194731-94-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-benzyloxy-1-{1-[1-(2-fluoro-ethyl)-azetidin-3-yl]-2,3-dihydro-1H-indol-5-yl}-1H-pyridin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-benzyloxy-1-{1-[1-(2-fluoro-ethyl)-azetidin-3-yl]-2,3-dihydro-1H-indol-5-yl}-1H-pyridin-2-one(1194731-94-6)
• EPA Substance Registry System: 4-benzyloxy-1-{1-[1-(2-fluoro-ethyl)-azetidin-3-yl]-2,3-dihydro-1H-indol-5-yl}-1H-pyridin-2-one(1194731-94-6)

Safety Data

• Hazardous Substances Data: 1194731-94-6(Hazardous Substances Data)

Upstream product

• 128071-98-7 4-bromo-2-fluoropyridine 
• 2683-66-1 4-benzyloxypyridine-N-oxide 
• 53937-02-3 4-(benzyloxy)pyridin-2(1H)-one 
• 1194732-41-6 C₁₁H₁₃BrN₂ 
• 1194732-26-7 5-bromo-1-[1-(2-fluoro-ethyl)-azetidin-3-yl]-2,3-dihydro-1H-indole 
• 762-49-2 2-fluoroethyl bromide 
• 1194731-96-8 1-(1-azetidin-3-yl-2,3-dihydro-1H-indol-5-yl)-4-benzyloxy-1H-pyridin-2-one 
• 1187744-24-6 4-(4-chlorophenyl)-2-fluoropyridine 
• 1173155-38-8 4-(4-chloro-phenyl)-1H-pyridin-2-one 
• 1194732-27-8 3-{5-[4-(4-chloro-phenyl)-2-oxo-2H-pyridin-1-yl]-2,3-dihydro-indol-1-yl}-azetidine-1-carboxylic acid 
• 1194732-49-4 C₂₈H₃₁N₃O₄ 
• 1194732-22-3 3-(5-bromo-2,3-dihydro-indol-1-yl)-azetidine-1-carboxylic acid tert-butyl ester 
• 22190-33-6 5-bromoindoline 

Relevant articles and documents

Strategies to lower the Pgp efflux liability in a series of potent indole azetidine MCHR1 antagonists

A series of potent indolyl azetidine rMCHR1 antagonists were found to show poor CNS penetration due to Pgp efflux. We envisioned a strategy which included: lowering basicity; changing the conformational flexibility motif; and removal of a hydrogen bond donor, in an attempt to optimize this property while maintaining target receptor efficacy. This work resulted in mitigation of Pgp efflux, and led us to identify 1-dihydroindolyl azetidine derivatives with CNS penetration and excellent rMCHR1 binding affinity.