119475-97-7Relevant academic research and scientific papers
6,11-DIHYDRODIBENZOTHIEPIN-11-YL 3-QUINUCLIDINYL ETHERS: NEW POTENTIAL ANTIDEPRESSANTS AND ANTIHISTAMINE AGENTS
Polivka, Zdenek,Metys, Jan,Protiva, Miroslav
, p. 1806 - 1811 (2007/10/02)
Reactions of 11-chloro-6,11-dihydrodibenzothiepin and its 2-methyl derivative, and further of the methanesulfonates of 2-chloro- and 2-bromo-6,11-dihydrodibenzothiepin-11-ol with 3-quinuclidinol afforded the title ethers I-IV.The 2-methyl compound II (VUFB-17 088) showed significant antihistamine activity and the 2-chloro compound III (VUFB-17 089), having antireserpine and anticataleptic activity, proved a potential antidepressant agent.
