119477-85-9

Basic information

• Product Name: U-75302
• Synonyms: 6-[6-(3-HYDROXY-1E,5Z-UNDECADIENYL)-2-PYRIDINYL]-1,5-HEXANEDIOL;6-(6-(3R-HYDROXY-1E,5Z-UNDECADIEN-1-YL)-2-PYRIDINYL)-1,5S-HEXANEDIOL;U-75302;(5R)-6-[6-[(1E,3S,5Z)-3-Hydroxy-1,5-undecadienyl]-2-pyridinyl]-1,5-hexanediol;(5R)-6-[6-[(3S,2E,5Z)-3-Hydroxy-1,5-undecadienyl]-2-pyridinyl]-1,5-hexanediol
• CAS NO: 119477-85-9
• Molecular Formula: C22H35NO3
• Molecular Weight: 361.52
• Mol File: 119477-85-9.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 567.2 °C at 760 mmHg
• Flash Point: 296.8 °C
• Appearance: light yellow/oil
• Density: 1.058 g/cm³
• Vapor Pressure: 1.05E-13mmHg at 25°C
• Refractive Index: 1.557
• Storage Temp.: −20°C
• Solubility: DMSO: 10 mg/mL
• CAS DataBase Reference: U-75302(CAS DataBase Reference)
• NIST Chemistry Reference: U-75302(119477-85-9)
• EPA Substance Registry System: U-75302(119477-85-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 119477-85-9(Hazardous Substances Data)

Usage

Description

U-75302 is an LTB4 receptor antagonist with a Ki of 159 nM on guinea pig lung membranes. This activity is specific for the BLT1 receptor; U-75302 does not antagonize the binding of [3H]-LTB4 to the human BLT2 receptor.

Uses

U-75302 is a selective leukotriene B4 antagonist.

InChI:InChI=1/C22H35NO3/c1-2-3-4-5-6-7-13-21(25)16-15-19-11-10-12-20(23-19)18-22(26)14-8-9-17-24/h6-7,10-12,15-16,21-22,24-26H,2-5,8-9,13-14,17-18H2,1H3/b7-6-,16-15+/t21-,22+/m1/s1

Upstream product

• 127705-30-0 3-Nitro-benzenesulfonic acid (S)-2-hydroxy-6-(tetrahydro-pyran-2-yloxy)-hex-4-ynyl ester 
• 127705-31-1 (S)-1-(6-Bromo-pyridin-2-yl)-6-(tetrahydro-pyran-2-yloxy)-hex-4-yn-2-ol 
• 127705-32-2 (S)-6-(6-Bromo-pyridin-2-yl)-hexane-1,5-diol 
• 127760-25-2 2-((S)-4-Oxiranyl-but-2-ynyloxy)-tetrahydro-pyran 
• 131723-88-1 (+)-(R)-(Z)-1-trimethylsilylundec-5-en-1-yn-3-ol 
• 127705-33-3 (Z)-1-trimethylsilylundec-5-en-1-yn-3-one 
• 111137-93-0 (+)-(5Z)-(3R)-5-undecen-1-yn-3-ol 
• 127705-36-6 (S)-6-[6-((Z)-(R)-3-Hydroxy-undec-5-en-1-ynyl)-pyridin-2-yl]-hexane-1,5-diol 
• 116897-09-7 6-(6-bromopyridine-2-yl)-5-hexenoic acid 
• 129030-85-9 (+/-)-(5Z)-5-undecen-1-yn-3-ol 
• 116897-11-1 6-(6-Bromopyridine-2-yl)methyl-tetrahydropyran-2one 
• 17814-85-6 (4-carboxybutyl)triphenylphosphonium bromide 
• 34160-40-2 6-bromo-2-pyridinecarbaldehyde 
• 116897-21-3 6-[6-((Z)-3-Hydroxy-undec-5-en-1-ynyl)-pyridin-2-ylmethyl]-tetrahydro-pyran-2-one 

Relevant articles and documents

Asymmetric synthesis of the diastereoisomers of the leukotriene B4 antagonist, U-75302

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