119480-12-5Relevant academic research and scientific papers
Spectroscopic, antibacterial and anti-cancer studies of new platinum(II)-diethyldithiocarbamate mixed ligand complexes with phosphine or amine ligands
Adil, Syed Farooq,Al-Janabi, Ahmed S.,Al-Janabi, Emaad M. A.,Al-Jibori, Subhi A.,Faihan, Ahmed S.,Hatshan, Mohammad R.,Kadhum, Wesam R.
, (2021/12/27)
A series of new platinum(II) mixed ligand complexes of diethyldithiocarbamate (Et2DT) and phosphine or amine ligands of the type [Pt(Et2DT)2(diphosphine)] (3–6), [Pt(Et2DT)2(diamine)](7–8), [Pt(Et2DT)2(PPh3)2] (9) and [Pt(Et2DT)2(SPPh3)2](10) have been prepared in good yield and fully characterized by elemental analysis, conductivity measurements and spectroscopic data (i.r., 1H, 31P-{1H} nmr. Our interest in these types of complexes are based on the fact that these complexes are known for their promising biological activity, and could possess interesting coordination modes, which are poorly represented in the literature. Therefore, the prepared complexes were tested for their anti-bacterial against three types of pathogenic bacteria namely S. aureus, E. coli, and p. aeruginosa. In addition, four of the prepared complexes were screened for their anti-cancer activity against lung cancer cell lines, and that the [Pt(Et2DT)2(bipy)] was significantly more potent with IC50 value is 1.0 ± 0.2 μM, but the [Pt(Et2DT)2(dppf)] was practically inactive in the selected dose range with IC50 value is 32.0 ± 3.0 μM.
Multinuclear magnetic resonance studies of the reactions of bidentate ligands with Pt(S2CNEt2)2. Comparisons with the reactions of Pt(S2P{OEt}2)2
Colton, Ray,Ebner, Jennifer
, p. 1559 - 1563 (2008/10/08)
The interactions in dichloromethane solution of Pt(S2CNEt2)2 with a number of potentially bidentate ligands have been studied by multinuclear (31P, 77Se, 195Pt) magnetic resonance techniques. The ligands used (L-L′) were Ph2PCH2CH2PPh2 (dpe), Ph2AsCH2CH2PPh2 (ape), Ph2PCH2PPh2 (dpm), Ph2PCH2P(E)Ph2 (E = S, Se to give dpmS, dpmSe), and Ph2AsCH2CH2P(E)Ph2 (apeS, apeSe). In 1:1 proportions the ligands dpe, ape, and dpm all eventually give [(η2-L-L′)Pt(η2-S2CNEt 2)]+. With dpe, the reaction is fast and no intermediate is observed; with ape, (η1-ape)Pt(η1-S2CNEt 2)(η2-S2CNEt2) is observable and kinetic and thermodynamic data for its conversion to the final product were obtained. The overall reaction with dpm is very slow and involves both (η1-dpm)Pt(η1-S2CNEt 2)(η2-S2CNEt2) and the dimer cis,cis-[Pt2(S2CNEt2) 2(μ-dpm)2]2+. In 1:2 proportions [(η1-L-L′)2Pt(η2-S 2CNEt2)]+ (L-L′ = ape, dpm) are formed but there is no further reaction in the dpe system. The relative instability of chelated ape and dpm is confirmed by reaction of [(η2-L-L′)Pt(η2-S2CNEt 2)]+ with PPh3 to give [(η1-L-L′)(PPh3)Pt(η2-S 2SNEt2)]+. The reaction between Pt(S2CNEt2)2 and dpmSe in 1:1 proportions is extremely complicated and is determined by the reactivity of the P=Se bond. The initial products include (η1-L-L′)Pt(η2-S2CNEt 2)(η2-S2CNEt2) (L-L′ = dpmSe, dpm) and dpmSe2. The reaction proceeds slowly to give cis,cis-[Pt2(S2CNEt2) 2(μ-dpm)2]2+ and [(η2-dpm)Pt(η2-S2CNEt 2)]+ that then react with the generated dpmSe2 to reinsert Se into a Pt-P bond to give [(η2-dpmSe)Pt(η2-S2CNEt 2)]+ as the final product. In contrast, dpmS reacts cleanly to give (η1-dpmS)Pt(η1-S2CNEt 2)(η2-S2CNEt2) and then [(η2-dpmS)Pt(η2-S2CNEt 2)]+ due to the lower lability of the P=S bond. No further reaction occurs with either ligand in 1:2 proportions. The ligands apeE do not react with Pt(S2CNEt2)2 in dichloromethane solution.
