15730-38-8Relevant academic research and scientific papers
Vapour pressure and thermoanalytical study of diethyldithiocarbamates of platinum metals
Sysoev,Morozova,Zharkova,Igumenov,Semyannikov,Grankin
, p. 87 - 96 (1998)
A thermoanalytical study of the diethyldithiocarbamates of the platinum metals Pt(II), Pd(II), Rh(III), Ir(III) and Ru(III) was carried out by means of DTA techniques in an inert atmosphere and in vacuum. Decomposition temperatures were determined and the mass loss curves were obtained for these compounds in helium and in vacuum. The X-ray diffraction patterns of the solid products of M(dtk)n thermolysis were studied. The temperature dependences of the saturated vapour pressures of the listed chelates were measured by flow and Knudsen methods, and the vaporization parameters were determined.
Mixed Chloro-, NN-Dialkyldithiocarbamato-, and S-Alkyl NN-dialkyldithiocarbamate Complexes of Platinum(II). Crystal Structure of
Clemente, Dore A.,Faraglia, Giuseppina,Sindellari, Livia,Trincia, Lucio
, p. 1823 - 1826 (1987)
The platinum(II) complexes (1), (2), and (3) have been prepared and characterized by i.r. and 1H n.m.r. spectroscopy.The crystal and molecular structure of compound (3) has been solved by X-ray diffraction methods and refined by least squares to a final R value of 0.037.The platinum atom is bonded, in the usual square-planar arrangement, to the sulphur atoms of the bidentate -S2CNEt2 group, to the thiocarbonyl sulphur of the dithioester molecule, and to the chlorine atom.In solution the complexes release the weakly bonded dithioester molecule.
EXAFS and IR structural study of platinum-based anticancer drugs' degradation by diethyl dithiocarbamate
Bouvet, Diane,Michalowicz, Alain,Crauste-Manciet, Sylvie,Brossard, Denis,Provost, Karine
, p. 3393 - 3398 (2006)
Platinum compounds constitute a discrete class of DNA-damaging anticancer drug agents, including cisplatin, carboplatin, and oxaliplatin. The toxicity of such drugs raises the problem of waste detoxification. Diethyl dithiocarbamate (DDTC) is recommended by the World Heath Organization (WHO) for the destruction of cisplatin, but the degradation product has not been structurally characterized. This paper deals with the extended X-ray absorption fine structure (EXAFS) and IR structural study of the reaction products of DDTC with cisplatin, carboplatin, and oxaliplatin. Cisplatin and carboplatin give the same reaction product: Pt(DDTC)2. In the case of oxaliplatin, we observed the formation of [(diaminocyclohexane)(DDTC)Pt(II)]. In all cases, the replacement of labile ligands by strong ligands should lead to inactive compounds. Our results suggest that the WHO inactivation protocol might be extended to carboplatin and oxaliplatin. Nevertheless, this should be validated by toxicity tests of the degradation products.
Emitting-state properties of square-planar dithiocarbamate complexes of palladium(II) and platinum(II) probed by pressure-dependent luminescence spectroscopy
Genre, Caroline,Levasseur-Theriault, Genevieve,Reber, Christian
, p. 1625 - 1635 (2009)
Temperature- and pressure-dependent Raman and luminescence spectra of four crystalline complexes of palla- dium(II) and platinum(II) with chelating diethyldithiocarbamate (EDTC) and pyrrolidine-A-dithiocarbamate (PDTC) li- gands are reported. The crystal
Platinum complexation at sorption of hexachloroplatinate(IV) ion with fibrous N,S-containing sorbents based on polyacrylonitrile (of TIOPAN Type)
Simanova,Kuznetsova,Demidov,Knyaz'kov,Konovalov
, p. 1439 - 1445 (2001)
Sorption properties of fibrous nitrogen-containing sorbents based on polyacrylonitrile containing diethyldithiocarbamate (TIOPAN-2) and 8-mercaptoquinoline groups (TIOPAN-6) with respect to the platinum(IV) chloride complex were studied. The effects of th
Spectroscopic, antibacterial and anti-cancer studies of new platinum(II)-diethyldithiocarbamate mixed ligand complexes with phosphine or amine ligands
Adil, Syed Farooq,Al-Janabi, Ahmed S.,Al-Janabi, Emaad M. A.,Al-Jibori, Subhi A.,Faihan, Ahmed S.,Hatshan, Mohammad R.,Kadhum, Wesam R.
, (2021/12/27)
A series of new platinum(II) mixed ligand complexes of diethyldithiocarbamate (Et2DT) and phosphine or amine ligands of the type [Pt(Et2DT)2(diphosphine)] (3–6), [Pt(Et2DT)2(diamine)](7–8), [Pt(Et2DT)2(PPh3)2] (9) and [Pt(Et2DT)2(SPPh3)2](10) have been prepared in good yield and fully characterized by elemental analysis, conductivity measurements and spectroscopic data (i.r., 1H, 31P-{1H} nmr. Our interest in these types of complexes are based on the fact that these complexes are known for their promising biological activity, and could possess interesting coordination modes, which are poorly represented in the literature. Therefore, the prepared complexes were tested for their anti-bacterial against three types of pathogenic bacteria namely S. aureus, E. coli, and p. aeruginosa. In addition, four of the prepared complexes were screened for their anti-cancer activity against lung cancer cell lines, and that the [Pt(Et2DT)2(bipy)] was significantly more potent with IC50 value is 1.0 ± 0.2 μM, but the [Pt(Et2DT)2(dppf)] was practically inactive in the selected dose range with IC50 value is 32.0 ± 3.0 μM.
Cytotoxicity, anti-microbial studies of M(II)-dithiocarbamate complexes, and molecular docking study against SARS COV2 RNA-dependent RNA polymerase
Al-Janabi, Ahmed S. M.,Saleh, Abdulrahman M.,Hatshan, Mohammad R.
, p. 1104 - 1115 (2021/02/20)
Ten transition metal dithiocarbamate (DTC)complexes of the type [M(κ2-Et2DT)2] (1–5), and [M(κ2-PyDT)2] (6–10) (where M?=?Co, Ni, Cu, Pd, and Pt; Et2DT?=?diethyl dithiocarbamate; PyDT?=?pyrrolidine dithiocarbamate) were synthesized and characterized by different methods. The dithiocarbamate acted as bidentate chelating ligands to afford a tetrahedral complexes with Co(II) ion and square planner with other transition metal ions. The dithiocarbamate complexes showed good activity against the pathogen bacteria species. The results showed the Pt-dithiocarbamate complexes are more active against all the tested bacteria than the Pd-dithiocarbamate complex. The dithiocarbamate complexes displayed the maximum inhibition zone against E. coli bacteria, whereas the lowest activity of the dithiocarbamate against Salmonella typhimurium bacteria. The cytotoxicity of the Pd(II) and Pt(II) complexes was screened against the MCF-7 breast cancer cell line and the complexes showed moderate activity compared with the cis-platin. The results indicated that the MCF7 cells treated with 500?μgml of ligands and Pd(II) and Pt(II) complexes after 24 hr exposure showed intercellular space and dead cells. Finally, molecular docking studies were carried out to examine the binding mode of the synthesized compounds against the proposed target; SARS COV2 RNA-dependent RNA polymerase.
Synthesis, crystal structures, magnetic properties and photoconductivity of C60 and C70 complexes with metal dialkyldithiocarbamates M(R2dtc)x, where M = CuII, CuI, AgI, ZnII, CdII, HgII, Mn II, NiII, and PtII; R = Me, Et, and nPr
Konarev, Dmitri V.,Kovalevsky, Andrey Y.,Khasanov, Salavat S.,Saito, Gunzi,Lopatin, Dmitri V.,Umrikhin, Alexey V.,Otsuka, Akihiro,Lyubovskaya, Rimma N.
, p. 1881 - 1895 (2007/10/03)
New complexes of fullerenes C60 and C70 with metal dialkyldithiocarbamates, [M(R2dtc)x]·[C 60(70)]·[Solvent], R = Et [M = CuII (C60, 1; C70, 2), CuI (C60, 3; C70, 4), AgI (C60, 5), ZnII (C 60, 6), CdII (C60, 7; C70, 8), HgII (C60, 9), MnII (C70, 10)], R = Et and Me [M = CuII (C60, 11), and ZnII (C 60, 12)], and R = nPr [M = CuII (C60, 13), NiII (C60, 14), and PtII (C60, 15)] were obtained. M(R2dtc)x efficiently cocrystallized with fullerene molecules as tetrahedral monomers (6, 12), dimers (1, 7, 11), and tetramers (3, 4). Fullerene molecules form closely packed hexagonal and square layers in 1, 7, and 11, hexagonal and tetragonal 3D structures in 6 and 12, and island motifs in 3 and 4. Complexes 1-15 have a neutral ground state. However, the formation of the complexes with fullerenes changes the environment of paramagnetic CuII and MnII. The EPR spectra of 1, 2, 11, and 13 are essentially modified relative to those of pristine Cu(R 2dtc)2 because of a weak coordination of CuII to fullerene and a flattening of the central (NCS2)2Cu fragments. Complex 10 shows a spectrum exhibiting features from 50 to 600 mT and manifests strong antiferromagnetic coupling of spins with a Weiss temperature of -96 K and the maximum of magnetic susceptibility at 46 K. Such magnetic behavior can be explained by the formation of [Mn(Et2dtc) 2]2 dimers in 10. The illumination of the crystals of 1, 2, and 7 by white light results in up to a 103 increase in photocurrent. The photoconductivity spectra have maxima at 470, 450-650, and 660 nm for 1, 2, and 7, respectively. Photogeneration of free charge carriers is realized by photoexcitation of Cu(Et2dtc)2 in 1 and 2, and by charge transfer from Cd(Et2dtc)2 to C60 molecules in 7. The decrease of photocurrent in 1 and 7 in a weak magnetic field with B0 0.5 T was found. Wiley-VCH Verlag GmbH & Co. KGaA, 2006.
Antisymbiosis. Preferential coordination of anionic oxygen versus neutral sulfur donor atoms of methylsulfanyl- or methylsulfinyl-acetato, 2-benzoato and 2-phenolato to the cis-PtII(PPh3)2 and Pt II(dppe) residues
Battan, Laura,Fantasia, Serena,Manassero, Mario,Pasini, Alessandro,Sansoni, Mirella
, p. 555 - 564 (2008/10/09)
The interaction of an excess of the title ligands L- with the cis-Pt(phos)2 moieties gives compounds a-b cis-[Pt(L-O) 2(phos)2] (a, phos = P(Ph)3; b, phos = 1/2 dppe), in which O- is preferred to S-coordination. Such preference is confirmed by the fact that the same products are obtained by reaction of excess of L - with the previously reported a-d complexes [Pt(L-O,S)(phos) 2]+, (c, phos = PPh3, d, phos = 1/2 dppe), for which chelate ring opening occurs with rupture of Pt-S rather than Pt-O bonds. Compound a can be obtained also by oxidative addition of HL to [Pt(PPh 3)3]. The Pt-O bonds in compounds a-d are stable towards substitution by Me2SO, pyridine and tetramethylthiourea. Substitution of L's occurs with N,N′-diethyldithiocarbamate, which forms a very stable chelate with Pt(II). Thiourea and N,N′-dimethylthiourea also react, because they give rise to cyclometallated products [Pt(phos)2(NRC(S) NHR)]+ (R = H, CH3), with one ionised thioamido group, as revealed by an X-ray investigation of [Pt(PPh3)2(NHC(S) NH2)]+. The preference of O versus S coordination, as well as the stability of the Pt-O bonds, are discussed in terms of antisymbiosis.
Reactivity of rescue agents for cisplatin induced nephrotoxicity with Pt2(2,2′-bipyridine) 2(μ-N-acetyl-L-cysteinato-S)2
Mitchell, Kathryn A.,Jensen, Craig M.
, p. 103 - 106 (2008/10/08)
The reactivity of Pt2(2,2′-bipyridine) 2(μ-N-acetyl-L-cysteinato-S)2 (1) with a variety of rescue agents for cisplatin induced nephrotoxicity was determined at 25°C in aqueous solution. The observed relative reactivities were: sodium diethyldithiocarbamate > 2-mercaptopyrimidine, cysteine, 2-mercaptopyridine > 3-hydroxy-2-mercaptopyridine, 4-methyl-2-mercaptopyrimidine, thiourea > penicillamine, 2-aminoethanethiol. No reaction was observed between complex 1 and either potassium thiocyanate or glycine within 3 h. The reaction products: Pt(ddtc)2, Pt(2,2′-bipyridine)(η2-D-cysteinato-N,S), Pt(2,2′-bipyridine)(η1-thiourea-S)2, Pt(2,2′-bipyridine)(η2-D-penicillamine-N,S) and [Pt(2,2′-bipyridine)(η2-2-aminoethanethiolate-N,S)] + were identified by 1H and 13C NMR spectroscopy. The reaction of 1 and the 2-mercaptohetrocycles gave a complex mixture of products which were not identified. In view of 2-mercaptopyrimidine's relatively high reactivity, low toxicity and formation of a water soluble product, it appears to have the greatest potential as a therapeutic for cisplatin nephrotoxicity among the tested rescue agents.
