15730-38-8

Basic information

• Product Name: Bis (N, N-diethyldithiocarbamato)platinum(II)
• Synonyms: Bis (N, N-diethyldithiocarbamato)platinum(II);Bis(diethyldithiocarbamato)platinum;Bis(N, N-diethyldithiocarbamato)platinum;Platinum, bis (diethylcarbamodithioato-S,S)-, (SP-4-1)-;Platinum, bis (diethyldithiocarbamato)-
• CAS NO: 15730-38-8
• Molecular Formula: C₁₀H₂₀N₂PtS₄
• Molecular Weight: 495.64
• Mol File: 15730-38-8.mol
• Article Data: 13

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Bis (N, N-diethyldithiocarbamato)platinum(II)(CAS DataBase Reference)
• NIST Chemistry Reference: Bis (N, N-diethyldithiocarbamato)platinum(II)(15730-38-8)
• EPA Substance Registry System: Bis (N, N-diethyldithiocarbamato)platinum(II)(15730-38-8)

Safety Data

• Hazardous Substances Data: 15730-38-8(Hazardous Substances Data)

Upstream product

• 162048-52-4 [Pt(ethylenediamine)((methylsulfanyl)acetato)]NO₃ 
• 20624-25-3 sodium diethyldithiocarbamate trihydrate 
• 148-18-5 sodium N,N-diethyldithiocarbamate 
• 13965-31-6 dichloro(2,2'-bipyridine)platinum(II) 
• 10025-99-7 potassium tetrachloroplatinate(II) 
• 120325-84-0 chloro[diethylenetriamine]platinum(II) chloride 
• 10025-65-7 platinum(II) chloride 
• 97-77-8 disulfiram 
• 63222-33-3 chloro(dimethylphosphinothioato)(methyldiphenylphosphine)platinum(II) 
• 41575-94-4 carboplatinum 
• 392-74-5 diethyldithiocarbamate 
• 15663-27-1 cisplatin 

Downstream Products

• 119480-19-2 {(η1-Ph2PCH2PPh2)2Pt(η2-S2CNEt2)}(1+) 
• 119480-12-5 {(η1-dpm)Pt(η2-S2CN(C2H5)2)(η1-S2CN(C2H5)2)} 
• 119502-85-1 {(η2-dpm)Pt(η2-S2CN(C2H5)2)}{BPh4} 
• 151893-18-4 {(η3-tris(2-diphenylphosphinoethyl)phosphine)Pt(η2-S2CNEt2)}{BPh4} 
• 64459-64-9 NN-diethyldithiocarbamatobis(methyldiphenylphosphinite)platinum(II)tetraphenylborate 
• 64459-65-0 NN-diethyldithiocarbamato(diphenylphosphinito)(methyl diphenylphosphinite)platinum(II) 

Relevant articles and documents

Vapour pressure and thermoanalytical study of diethyldithiocarbamates of platinum metals

A thermoanalytical study of the diethyldithiocarbamates of the platinum metals Pt(II), Pd(II), Rh(III), Ir(III) and Ru(III) was carried out by means of DTA techniques in an inert atmosphere and in vacuum. Decomposition temperatures were determined and the mass loss curves were obtained for these compounds in helium and in vacuum. The X-ray diffraction patterns of the solid products of M(dtk)n thermolysis were studied. The temperature dependences of the saturated vapour pressures of the listed chelates were measured by flow and Knudsen methods, and the vaporization parameters were determined.

EXAFS and IR structural study of platinum-based anticancer drugs' degradation by diethyl dithiocarbamate

Platinum compounds constitute a discrete class of DNA-damaging anticancer drug agents, including cisplatin, carboplatin, and oxaliplatin. The toxicity of such drugs raises the problem of waste detoxification. Diethyl dithiocarbamate (DDTC) is recommended by the World Heath Organization (WHO) for the destruction of cisplatin, but the degradation product has not been structurally characterized. This paper deals with the extended X-ray absorption fine structure (EXAFS) and IR structural study of the reaction products of DDTC with cisplatin, carboplatin, and oxaliplatin. Cisplatin and carboplatin give the same reaction product: Pt(DDTC)2. In the case of oxaliplatin, we observed the formation of [(diaminocyclohexane)(DDTC)Pt(II)]. In all cases, the replacement of labile ligands by strong ligands should lead to inactive compounds. Our results suggest that the WHO inactivation protocol might be extended to carboplatin and oxaliplatin. Nevertheless, this should be validated by toxicity tests of the degradation products.

Platinum complexation at sorption of hexachloroplatinate(IV) ion with fibrous N,S-containing sorbents based on polyacrylonitrile (of TIOPAN Type)

Sorption properties of fibrous nitrogen-containing sorbents based on polyacrylonitrile containing diethyldithiocarbamate (TIOPAN-2) and 8-mercaptoquinoline groups (TIOPAN-6) with respect to the platinum(IV) chloride complex were studied. The effects of th

Cytotoxicity, anti-microbial studies of M(II)-dithiocarbamate complexes, and molecular docking study against SARS COV2 RNA-dependent RNA polymerase

Ten transition metal dithiocarbamate (DTC)complexes of the type [M(κ2-Et2DT)2] (1–5), and [M(κ2-PyDT)2] (6–10) (where M?=?Co, Ni, Cu, Pd, and Pt; Et2DT?=?diethyl dithiocarbamate; PyDT?=?pyrrolidine dithiocarbamate) were synthesized and characterized by different methods. The dithiocarbamate acted as bidentate chelating ligands to afford a tetrahedral complexes with Co(II) ion and square planner with other transition metal ions. The dithiocarbamate complexes showed good activity against the pathogen bacteria species. The results showed the Pt-dithiocarbamate complexes are more active against all the tested bacteria than the Pd-dithiocarbamate complex. The dithiocarbamate complexes displayed the maximum inhibition zone against E. coli bacteria, whereas the lowest activity of the dithiocarbamate against Salmonella typhimurium bacteria. The cytotoxicity of the Pd(II) and Pt(II) complexes was screened against the MCF-7 breast cancer cell line and the complexes showed moderate activity compared with the cis-platin. The results indicated that the MCF7 cells treated with 500?μgml of ligands and Pd(II) and Pt(II) complexes after 24 hr exposure showed intercellular space and dead cells. Finally, molecular docking studies were carried out to examine the binding mode of the synthesized compounds against the proposed target; SARS COV2 RNA-dependent RNA polymerase.