119484-01-4

Upstream product

• 98796-53-3 N₆-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine-3'-O-[O-(2-cyanoethyl)-N,N'-diisopropylphosphoramidite] 
• 76101-30-9 2-cyanoethyl phosphorodichloridite 
• 64325-78-6 N₆-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine 
• 117133-23-0 2-cyanoethyl phosphorobistriazolidite 
• 133519-14-9 Phosphorous acid (2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester bis-(2,2,2-trifluoro-1-trifluoromethyl-ethyl) ester 
• 109-78-4 3-Hydroxypropionitrile 
• 78635-98-0 3'-O-levulinoylthymidine 

Downstream Products

• 119484-02-5 Phosphorochloridous acid (2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester 
• 64325-78-6 N₆-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine 
• 119484-03-6 C₆₅H₅₉N₈O₁₄P 
• 119484-04-7 C₆₅H₅₉N₈O₁₅P 
• 104684-74-4 C₃₈H₃₆N₅O₈P 
• 71100-65-7 C₄₁H₃₈N₆O₉P^(1-) 

Relevant academic research and scientific papers

Solution-phase synthesis of branched DNA hybrids via H -phosphonate dimers

A method for the solution-phase synthesis of branched oligonucleotides with tetrahedral or pseudo-octahedral geometry is described that involves the coupling of 3′-H-phosphonates of protected dinucleoside phosphates and organic core molecules. The dimer building blocks are produced by a synthesis that requires no chromatographic purification and that produces the dimer H-phosphonates in up to 44% yield in less than three days of laboratory work. A total of seven different branched hybrids were prepared, including a new hybrid of the sequence (CG)4TBA, where TBA stands for tetrakis(p- hydroxybiphenyl)adamantane that assembles into a material from micromolar aqueous solution upon addition of MgCl2.

High-yield solution-phase synthesis of di- and trinucleotide blocks assisted by polymer-supported reagents

(Chemical Equation Presented) A new solution-phase phosphoramidite approach is reported for oligonucleotide synthesis employing recyclable solid-supported reagents. It uses polyvinyl pyridinium tosylate as the activator of a nucleoside-3′-O-phosphoramidit

Solid phase oligonucleotide synthesis by using β-CE H-phosphonate approach

A new approach to the solid phase synthesis of oligonucleotide is described, which is based on oxidative coupling of nucleoside 3′-β-CE H-phosphonates in presence of N-Bromosuccinimide (NBS) as a coupling agent.

Commercially available 5'-DMT phosphoramidites as reagents for the synthesis of vinylphosphonate-linked oligonucleic acids.

[reaction: see text]. Commercially available cyanoethyl phosphoramidites derived from T, d(C), d(A), and d(G) were hydrolyzed (1H-tetrazole, MeCN/H2O) to give the corresponding H-phosphonates in excellent yields. Palladium(0)-catalyzed cross-coupling of e

Nucleoside Phosphite, 0-Bis(1,1,1,3,3,3-hexafluoro-2-propyl) Deoxyribonucleosid-3'-yl Phospites. A Versatile Synthetic Intermediate for Phosphonate Modified Nucleotide and Oligonucleotide Synthesis

The 0-bis(1,1,1,3,3,3-hexa-fluoro-2-propyl) deoxyribonucleosid-3'-yl phosphite units could be converted into the 0-nucleosid-3'-yl phosphonate, 0-2-cyanoethyl 0-nucleosid-3'-yl phosphonate, and 0-1,1,1,3,3,3-hexafluoro-2-propyl 0-nucleosid-3'yl phosphonot

2-CYANOETHYL NUCLEOSIDE 3'-PHOSPHONATES AS NOVEL STARTING MATERIALS FOR OLIGONUCLEOTIDE SYNTHESIS

Various disubstituted phosphonates including alkylnucleoside 3'-phosphonates were converted rapidly into the corresponding phosphorochloridites by use of tris(2,4,6-tribromophenoxy)dichlorophosphorane (BDCP) as a chlorinating reagent.The reaction was found to be applicable to the rapid and practical synthesis of oligonucleotides.