1195-40-0

Usage

Uses

Used in Organic Synthesis:
6-methylpyridine-2-carbaldehyde oxime serves as a valuable building block in organic synthesis, contributing to the preparation of a diverse range of organic compounds. Its unique structure and reactivity make it a key component in the synthesis of complex organic molecules.
Used in Pharmaceutical Applications:
6-methylpyridine-2-carbaldehyde oxime is utilized in the development of pharmaceuticals due to its potential biological activity. Its presence in drug molecules can enhance their efficacy and selectivity, making it a promising candidate for the creation of new therapeutic agents.
Used as a Chelating Agent:
6-methylpyridine-2-carbaldehyde oxime is employed as a chelating agent, capable of forming stable complexes with metal ions. This property is crucial in various chemical processes, including the purification of metal ions and the development of metal-based catalysts.
Used as a Ligand in Coordination Chemistry:
In coordination chemistry, 6-methylpyridine-2-carbaldehyde oxime acts as a ligand, binding to metal centers to form coordination compounds. Its ability to coordinate with metals expands its utility in the design of new materials with specific properties and applications.
Used in Pesticide Development:
6-methylpyridine-2-carbaldehyde oxime's potential as a pesticide is being explored due to its biological activity. It may be incorporated into formulations to control pests in agriculture, offering an alternative to existing chemical pesticides.
Overall, 6-methylpyridine-2-carbaldehyde oxime is a versatile compound with applications spanning across multiple industries, from chemical synthesis to pharmaceutical development and beyond. Its unique properties and potential uses make it an important player in the advancement of science and technology.

InChI:InChI=1/C7H8N2O/c1-6-3-2-4-7(9-6)5-8-10/h2-5,9H,1H3/b7-5-

Upstream product

• 1122-72-1 6-methyl-2-pyridinecarboxaldehyde 
• 1122-71-0 2-(Hydroxymethyl)-6-methylpyridine 
• 1073-23-0 2,6-lutidine N-oxide 
• 108-48-5 2,6-dimethylpyridine 

Downstream Products

• 1365836-53-8 (6-methylpyridin-2-yl)methanamine dihydrochloride 
• 1365836-53-8 2-(aminomethyl)-5-methylpyridine hydrochloride 
• 63668-37-1 6-methylpyridine-2-carboxamide 

Relevant academic research and scientific papers

Methyl Scanning and Revised Binding Mode of 2-Pralidoxime, an Antidote for Nerve Agent Poisoning

Organophosphorus nerve agents (OPNAs) inhibit acetylcholinesterase (AChE) and, despite the Chemical Weapons Convention arms control treaty, continue to represent a threat to both military personnel and civilians. 2-Pralidoxime (2-PAM) is currently the only therapeutic countermeasure approved by the United States Food and Drug Administration for treating OPNA poisoning. However, 2-PAM is not centrally active due to its hydrophilicity and resulting poor blood-brain barrier permeability; hence, these deficiencies warrant the development of more hydrophobic analogs. Specifically, gaps exist in previously published structure activity relationship (SAR) studies for 2-PAM, thereby making it difficult to rationally design novel analogs that are concomitantly more permeable and more efficacious. In this study, we methodically performed a methyl scan on the core pyridinium of 2-PAM to identify ring positions that could tolerate both additional steric bulk and hydrophobicity. Subsequently, SAR-guided molecular docking was used to rationalize hydropathically feasible binding modes for 2-PAM and the reported derivatives. Overall, the data presented herein provide new insights that may facilitate the rational design of more efficacious 2-PAM analogs.

ANALOGS OF 2-PRALIDOXIME AS ANTIDOTES AGAINST ORGANOPHOSPHORUS NERVE AGENTS

Provided herein are compounds useful in treating exposure to an organophosphorus compound, such as a nerve agent, pesticide, or, generally, an acetylcholinesterase inhibitor, such as sarin. Compositions, e.g. pharmaceutical compositions or dosage forms, comprising the compounds also are provided herein. Methods of treating a patient exposed to a nerve agent, pesticide, or, generally, an acetylcholinesterase inhibitor, e.g., an organophosphorus compound, such as sarin, also are provided.

Aminoheteroaryl benzamides as kinase inhibitors

The present invention provides a compound of Formula (I) or a salt thereof; and therapeutic uses of these compounds. The present invention further provides pharmaceutical compositions comprising these compounds, and compositions comprising these compounds with a therapeutic co-agent.