1195-75-1

Upstream product

• 557-99-3 acetyl fluoride 
• 19980-35-9 1-trimethylsilyloxy-2-methyl-1-cyclohexene 
• 93845-25-1 2-(2-Benzenesulfonyl-acetyl)-2-methyl-cyclohexanone 
• 108-24-7 acetic anhydride 
• 583-60-8 2-Methylcyclohexanone 
• 15867-49-9 3-methyl-7-octene-2,4-dione 
• 74-88-4 methyl iodide 
• 7637-07-2 boron trifluoride 
• 1196-73-2 1-acetoxy-2-methylcyclohexene 
• 75-36-5 acetyl chloride 
• 1035809-63-2 2-<1-(2'-bromobenzyloxy)ethyl>-2-methylcyclohexanone 
• 78747-30-5 2-Hydroxy-2-(1-methyl-2-oxo-cyclohexyl)-propionitrile 
• 874-23-7 2-acetylcyclohexanone 

Downstream Products

• 99183-34-3 6-methyl-7-oxooctanoic acid 
• 583-60-8 2-Methylcyclohexanone 
• 5601-58-1 rac-methyl 6-methyl-7-oxooctanoate 
• 117212-79-0 methyl 2,3-dimethylcyclohex-1-enecarboxylate 

Relevant academic research and scientific papers

Acylation of Ketone Silyl Enol Ethers with Acetyl Tetrafluoroborate. A Synthesis of 1,3-Diketones

Silyl enol ethers, obtained by silylation of ketones, are acylated with acetyl tetrafluoroborate to give 1,3-diketones in reasonable yields.Thetert-butyldimethylsilyl enol ether of cyclohexanone gives a nearly quantitative yield of acetylcyclohexanone, while the trimethylsilyl enol ethers of cyclohexanone and other ketones give moderate yields of the corresponding 1,3-diketones.The regiospecificity of the reaction was studied with the isomeric silyl enol ethers of 2-methylcyclohexanone.

INDICYANINE DYES AND THE DERIVATIVES THEREOF FOR ANALYSING BIOLOGICAL MICROMOLECULES

The invention relates to two series of synthesised indolenine pentamethine dyes (37 compounds) comprising a reactive group in the third and fifth positions of the indolenine cycle, respectively. A method for producing, extracting and purifying the dyes and the precursors thereof, consisting in determining the absorption and fluorescence maxima, molecular extinction factors, fluorescence quantum yields, relative fluorescence effectiveness at excitation on a wavelength of 635 nm (detection of 670 nm) and 655 nm (detection of 690 nm), relative light stability and comparative sensitivity of detection of marked oligonucleotides on biochips of the claimed dyes, is disclosed. The use of the claimed dyes in the form of fluorescent marks for oligonucleotide and protein chips is also disclosed.

Synthesis of carboxyalkylindolenines from 6-methyl-7-oxooctanoic acid

Novel 3-(4-carboxybutyl)indolenines were obtained. A method for the synthesis of 6-methyl-7-oxooctanoic acid, the precursor for these indolenines, was developed.

New applications of 1,5-hydrogen atom transfer reactions: Self-oxidizing protecting groups

Three new alcohol protecting groups are introduced: o-bromobenzyl, o-bromo(methylenedioxy)benzyl, and o-bromotrityl. Removal of these protecting groups under reductive conditions with tributyltin hydride is coupled with an oxidation of the substrate to produce directly an aldehyde or ketone. This oxidation occurs by 1,5-hydrogen transfer, followed by β-fragmentation. For example, treatment of the o-bromobenzyl ether of 3-phenyl-1-propanol with tibutyltin hydride at 0.001 M (80°C) directly produces 3-phenyl-1-propanal. An application to the selective oxidation of primary alcohols in the presence of secondary alcohols is also introduced.

TWO-CARBON MICHAEL ACCEPTORS. ACETYL CATION EQUIVALENTS

Base-induced Michael condensation of chloromethoxyvinyl phenyl sulfoxides or sulfones with active methylene compounds were examined.The newly introduced functionalized substituents were converted into acetyl group by the subsequent treatment.

THE SYNTHESIS OF SELECTIVELY PROTECTED β-DIKETONES AND β-KETOALDEHYDES

The reaction of acyl cyanides with enol silyl ethers produces β-cyano, β-hydroxy carbonyl compounds.