1195-99-9

Basic information

• Product Name: 2-PHENYLPROP-2-YLISOCYANIDE
• Synonyms: 2-PHENYLPROP-2-YLISOCYANIDE
• CAS NO: 1195-99-9
• Molecular Formula: C₁₀H₁₁N
• Molecular Weight: 145.2
• Mol File: 1195-99-9.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-PHENYLPROP-2-YLISOCYANIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-PHENYLPROP-2-YLISOCYANIDE(1195-99-9)
• EPA Substance Registry System: 2-PHENYLPROP-2-YLISOCYANIDE(1195-99-9)

Safety Data

• Hazardous Substances Data: 1195-99-9(Hazardous Substances Data)

Upstream product

• 42044-69-9 N-formyl-α,α-dimethylbenzylamine 
• 1895-39-2 sodium chlorodifluoroacetate 
• 585-32-0 2-phenyl-2-propylamine 
• 21872-32-2 1-phenylethyl isocyanide 
• 74-88-4 methyl iodide 
• 3575-19-7 2-bromo-2-phenylpropane 
• 2942-58-7 diethyl cyanophosphonate 
• 612058-36-3 (1-methyl-1-phenylethoxy)di(phenyl)phosphine 
• 617-94-7 1-methyl-1-phenylethyl alcohol 

Downstream Products

• 1195-98-8 2-methyl-2-phenylpropionitrile 
• 98-83-9 isopropenylbenzene 

Relevant articles and documents

Method for preparing isonitrile compound

The invention discloses a method for preparing an isonitrile compound, and belongs to the field of organic synthesis. According to the method, sodium chlorodifluoroacetate or potassium bromodifluoroacetate is used as a difluoromethyl source and is condensed with primary amine under the action of alkali to obtain an isocyanide target product, so that isocyanide is generated in situ on the primary amine. The reaction raw materials, alkali and solvent used in the method are simple and easy to obtain, wide in source and convenient to operate, do not need special storage and use conditions, the method has the advantages of safety, low cost, high yield, simple process, environmental friendliness and the like, and has important application value in the fields of medicine, protein and polypeptidepreparation, pesticides, high polymer materials, dyes and the like.

Synthesis of isocyanides by reacting primary amines with difluorocarbene

A general, convenient, and friendly route for preparing a versatile building block of isocyanides from primary amines is developed. Difluorocarbene, generated in situ from decarboxylation of chlorodifluoroacetate, reacts efficiently with primary amines to produce isocyanides. Various primary amines are well tolerated, including aryl, heteroaryl, benzyl, and alkyl amines, as well as amine residues in amino acids and peptides. Late-stage functionalization of biologically active amines is demonstrated, showing its practical capacity in drug design and peptide modification.

Cyanation of alcohols with diethyl cyanophosphonate and 2,6-dimethyl-1,4-benzoquinone by a new type of oxidation-reduction condensation

Cyanation of various alcohols by a new type of oxidation-reduction condensation is described. Primary alkyl diphenylphosphinites, 2,6-dimethyl-1,4-benzoquinone (DMBQ), and diethyl cyanophosphonate gave the corresponding nitriles in high yields. During the above experiment on cyanation of 4-phenylbutan-2-ol, the unexpected formation of a mixture of nitrile and isocyanide was observed. After careful examination of the reaction conditions, selective synthesis of isocyanides from secondary alcohols was successfully accomplished by the use of zinc oxide (ZnO) as an additive. Reaction of tertiary alcohols provided the corresponding isocyanides exclusively in the absence of an additive. Cyanation of optically active alcohols was tried in order to clarify the stereochemistry of this reaction, and the reaction was thus proved to proceed with the inversion of configuration.