119540-32-8Relevant articles and documents
SAR studies of 1,5-diarylpyrazole-based CCK1 receptor antagonists
Gomez, Laurent,Hack, Michael D.,McClure, Kelly,Sehon, Clark,Huang, Liming,Morton, Magda,Li, Lina,Barrett, Terrance D.,Shankley, Nigel,Breitenbucher, J. Guy
, p. 6493 - 6498 (2008/04/02)
A high throughput screening campaign revealed compound 1 as a potent antagonist of the human CCK1 receptor. Here, we report the syntheses and SAR studies of 1,5-diarylpyrazole analogs with various structural modifications of the alkane side cha
Pharmacologically active 2- and 3-substituted (1',5'-diaryl-3-pyrazolyl)-N-hydroxypropanamides
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, (2008/06/13)
2- and 3-substituted (1',5'-diaryl-3'-pyrazolyl)-N-hydroxypropanamides, a method for their preparation, compositions containing the same and methods of their use are disclosed. The N-hydroxypropanamides are useful in alleviating inflammatory and cardiovascular disorders in mammals.