119540-32-8

Upstream product

• 122-00-9 para-methylacetophenone 
• 95-92-1 oxalic acid diethyl ester 
• 3471-32-7 4-Methoxyphenylhydrazine 

Downstream Products

• 119517-52-1 (E)-3-(6-Methoxy-naphthalen-2-yl)-3-[1-(4-methoxy-phenyl)-5-p-tolyl-1H-pyrazol-3-yl]-acrylic acid ethyl ester 
• 119517-53-2 (Z)-3-(6-Methoxy-naphthalen-2-yl)-3-[1-(4-methoxy-phenyl)-5-p-tolyl-1H-pyrazol-3-yl]-acrylic acid ethyl ester 
• 119517-65-6 (E)-3-Biphenyl-4-yl-3-[1-(4-methoxy-phenyl)-5-p-tolyl-1H-pyrazol-3-yl]-acrylic acid ethyl ester 
• 119517-64-5 (Z)-3-Biphenyl-4-yl-3-[1-(4-methoxy-phenyl)-5-p-tolyl-1H-pyrazol-3-yl]-acrylic acid ethyl ester 
• 119517-68-9 (E)-3-[1-(4-Methoxy-phenyl)-5-p-tolyl-1H-pyrazol-3-yl]-3-naphthalen-2-yl-acrylic acid ethyl ester 
• 119517-67-8 (Z)-3-[1-(4-Methoxy-phenyl)-5-p-tolyl-1H-pyrazol-3-yl]-3-naphthalen-2-yl-acrylic acid ethyl ester 
• 119517-66-7 (E)-3-[1-(4-Methoxy-phenyl)-5-p-tolyl-1H-pyrazol-3-yl]-3-naphthalen-1-yl-acrylic acid ethyl ester 
• 119517-18-9 (Z)-3-[1-(4-Methoxy-phenyl)-5-p-tolyl-1H-pyrazol-3-yl]-3-naphthalen-1-yl-acrylic acid ethyl ester 
• 119517-47-4 (E)-3-(2-Methoxy-phenyl)-3-[1-(4-methoxy-phenyl)-5-p-tolyl-1H-pyrazol-3-yl]-acrylic acid ethyl ester 
• 119517-19-0 (Z)-3-(2-Methoxy-phenyl)-3-[1-(4-methoxy-phenyl)-5-p-tolyl-1H-pyrazol-3-yl]-acrylic acid ethyl ester 
• 119517-48-5 Ethyl E-3-(4-Methoxyphenyl)-3-<1-(4-methoxyphenyl)-5-(4-methylphenyl)-3-pyrazolyl>propenoate 
• 119517-49-6 Ethyl Z-3-(4-Methoxyphenyl)-3-<1-(4-methoxyphenyl)-5-(4-methylphenyl)-3-pyrazolyl>propenoate 
• 119517-51-0 (Z)-3-[1-(4-Methoxy-phenyl)-5-p-tolyl-1H-pyrazol-3-yl]-3-thiophen-2-yl-acrylic acid ethyl ester 
• 119517-50-9 (E)-3-[1-(4-Methoxy-phenyl)-5-p-tolyl-1H-pyrazol-3-yl]-3-thiophen-2-yl-acrylic acid ethyl ester 

Relevant academic research and scientific papers

SAR studies of 1,5-diarylpyrazole-based CCK1 receptor antagonists

A high throughput screening campaign revealed compound 1 as a potent antagonist of the human CCK1 receptor. Here, we report the syntheses and SAR studies of 1,5-diarylpyrazole analogs with various structural modifications of the alkane side cha

Pyrazole CCK1 receptor antagonists. Part 1: Solution-phase library synthesis and determination of Free-Wilson additivity

High throughput screening revealed compound 1 as a potent antagonist of the CCK1 receptor. Evaluation of the CCK1 SAR in a series of these diarylpyrazole antagonists was conducted in a matrix synthesis format revealing additive (Free

Pharmacologically active 2- and 3-substituted (1',5'-diaryl-3-pyrazolyl)-N-hydroxypropanamides

2- and 3-substituted (1',5'-diaryl-3'-pyrazolyl)-N-hydroxypropanamides, a method for their preparation, compositions containing the same and methods of their use are disclosed. The N-hydroxypropanamides are useful in alleviating inflammatory and cardiovascular disorders in mammals.

A Simple Regioselective Synthesis of Ethyl 1,5-Diarylpyrazole-3-carboxylates

Improved procedures for the regioselective preparation of ethyl 1,5-diarylpyrazole-3-carboxylates are described.The new procedures utilize prepared lithium aroylpyruvate intermediates which, when combined with arylphenylhydrazine hydrochlorides from 1,5-d