119541-01-4

Upstream product

• 932-41-2 2,3-diformylthiophene 
• 100-46-9 benzylamine 
• 100-52-7 benzaldehyde 
• 27757-86-4 (3-thienylmethyl)amine 
• 110409-90-0 diformyl-2,3 thiophene (CDO-2) 

Relevant academic research and scientific papers

Site-Selective Carbonylative Synthesis of Structurally Diverse Lactams from Heterocyclic Amines with TFBen as the CO Source

A palladium-catalyzed site-selective C-H carbonylation of heterocyclic amines for the synthesis of lactam motifs has been developed. The reaction of 3-thiophene methylamines, 2-thiophene methylamines, and tryptamines with benzene-1,3,5-triyl triformate (TFBen) as the CO source provides a series of structurally diverse lactams in moderate to high yields with excellent regioselectivities.

Synthesis and structure elucidation of the condensation products between thiophene dicarbaldehydes and aromatic amines. Potential analgesic and anti-inflammatory agents

Thiophene-3,4-dicarbaldehyde I reacts in the presence of 2-mercaptoethanol to yield N-aryl-5,6-dihydro-4-oxo-4H-thieno[3,4-c]pyrroles 2 and N-aryl-4-arylimino-5,6-dihydro-4H-thieno[3,4-c]pyrroles 3, while thiophene 2,3-dicarbaldehyde 4 reacts with aromatic amines to give N-aryl-5,6-dihydro-6-oxo-4H-thieno[2,3-c]pyrroles 5 in good yields. Labeling experiments and nmr spectral analysis give evidence for the possible reaction mechanism.