119549-47-2Relevant academic research and scientific papers
Potent dipeptide inhibitors of the pp60(c-src) SH2 domain
Pacofsky, Gregory J.,Lackey, Karen,Alligood, Krystal J.,Berman, Judd,Charifson, Paul S.,Crosby, Renae M.,Dorsey Jr., George F.,Feldman, Paul L.,Gilmer, Tona M.,Hummel, Conrad W.,Jordan, Steven R.,Mohr, Christopher,Shewchuk, Lisa M.,Sternbach, Daniel D.,Rodriguez, Marc
, p. 1894 - 1908 (1998)
The design, synthesis, and evaluation of dipeptide analogues as ligands for the pp60(c-src) SH2 domain are described. The critical binding interactions between Ac-Tyr-Glu-N(n-C5H11)2 (2) and the protein are established and
From Kinase Inhibitors to Multitarget Ligands as Powerful Drug Leads for Alzheimer's Disease using Protein-Templated Synthesis
Nozal, Vanesa,García-Rubia, Alfonso,Cuevas, Eva P.,Pérez, Concepción,Tosat-Bitrián, Carlota,Bartolomé, Fernando,Carro, Eva,Ramírez, David,Palomo, Valle,Martínez, Ana
supporting information, p. 19344 - 19354 (2021/07/28)
Multitarget directed ligands (MTDLs) are arising as promising tools to tackle complex diseases. The main goal of this work is to create powerful modulating agents for neurodegenerative disorders. To achieve this aim, we have combined fragments that inhibi
Nitrogen positional scanning in tetramines active against HIV-1 as potential CXCR4 inhibitors
Puig De La Bellacasa, Raimon,Gibert, Albert,Planesas, Jesús M.,Ros-Blanco, Laia,Batllori, Xavier,Badía, Roger,Clotet, Bonaventura,Esté, José,Teixidó, Jordi,Borrell, José I.
, p. 1455 - 1472 (2016/02/03)
The paradigm, derived from bicyclams and other cyclams, by which it is necessary to use the p-phenylene moiety as the central core in order to achieve high HIV-1 antiviral activities has been reexamined for the more flexible and less bulky structures 4, p
BETA-LACTAMASE INHIBITORS
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Page/Page column 94-95, (2010/12/17)
Disclosed herein are α-aminoboronic acids and their derivatives which act as inhibitors of beta-lactamases. Also disclosed herein are pharmaceutical compositions comprising α-aminoboronic acids and methods of use thereof.
Small peptides containing phosphotyrosine and adjacent αMe- phosphotyrosine or its mimetics as highly potent inhibitors of Grb2 SH2 domain
Liu, Wang-Qing,Vidal, Michel,Gresh, Nohad,Roques, Bernard P.,Garbay, Christiane
, p. 3737 - 3741 (2007/10/03)
A series of small peptides with the sequence mAZ-pTyr-Xaa-Asn-NH2, where Xaa denotes α-methylphosphotyrosine or its carboxylic mimetics, were synthesized as inhibitors of the Grb2 SH2 domain. Peptide 3 with (α-Me)pTyr as Xaa has the highest aff
