13737-36-5Relevant articles and documents
Synthesis of α-Helices Having a Positively Charged Random Coil-Block on Either N- or C-Terminal
Takahashi, Sho,Hibino, Takeshi,Sawada, Seiji
, p. 2467 - 2472 (1988)
To study a charge-induced stabilization of α-helix, α-helical peptides having a positively charged random-coil block on either N- or C-terminal of the helix, and having a strictly defined length, (Ala)20(X)20Phe and (X)20(Ala)20Phe(X=Lys or Orn), were syn
Preparation method of netarsudil mesylate
-
Paragraph 0021, (2021/07/17)
The invention relates to a preparation method of netarsudil mesylate.Netarsudil mesylate is synthesized by utilizing chiral induction, and compared with an existing chiral HPLC method or SFC method, netarsudil mesylate prepared by adopting a chemical synt
BIARYL UREA DERIVATIVE OR SALT THEREOF, AND MANUFACTURING AND APPLICATION OF SAME
-
Paragraph 0173, (2019/05/10)
The present invention discloses a biaryl urea RORγt inhibitor, and specifically relates to a biaryl urea derivative, as represented by formula I, with an RORγt inhibiting activity, and a preparation process thereof, and a pharmaceutical composition comprising the compound. Further disclosed is use of the compound for treating an RORγt-related disease.