1195789-72-0Relevant academic research and scientific papers
TRICYCLIC ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS
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, (2009/12/23)
Described herein are compounds that are antagonists of PGD2 receptors. Also described are pharmaceutical compositions and medicaments that include the compounds described herein that are antagonists of PGD2 receptors. Also described herein are methods of
Novel tricyclic antagonists of the prostaglandin D2 receptor DP2 with efficacy in a murine model of allergic rhinitis
Stearns, Brian A.,Baccei, Christopher,Bain, Gretchen,Broadhead, Alex,Clark, Ryan C.,Coate, Heather,Evans, Jilly F.,Fagan, Patrick,Hutchinson, John H.,King, Christopher,Lee, Catherine,Lorrain, Daniel S.,Prasit, Peppi,Prodanovich, Pat,Santini, Angelina,Scott, Jill M.,Stock, Nicholas S.,Truong, Yen P.
scheme or table, p. 4647 - 4651 (2010/04/28)
The synthesis of a series of tricyclic antagonists for the prostaglandin D2 receptor DP2 (CRTH2) is disclosed. The activities of the compounds were evaluated in a human DP2 binding assay and a human whole blood eosinophil shape change assay. Po
