116026-98-3

Basic information

• Product Name: (2-BROMO-PYRIDIN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTER
• Synonyms: TERT-BUTYL 2-BROMOPYRIDIN-3-YLCARBAMATE;(2-BROMO-PYRIDIN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTER;(2-BROMO-3-PYRIDINYL)CARBAMIC ACID, 1,1-DIMETHYL ETHYL ESTER;2-BROMO-3-N-BOC-AMINOPYRIDINE;tert-Butyl 2-bromopyridin-3-ylcarbamate ,97%;2-Bromo-3[N-（tert-butyloxycar-bonyl)amino]pyridine;Zinc04352714;tert-butyl N-(2-broMopyridin-3-yl)carbaMate
• CAS NO: 116026-98-3
• Molecular Formula: C₁₀H₁₃BrN₂O₂
• Molecular Weight: 273.13
• Mol File: 116026-98-3.mol
• Article Data: 14

Chemical Properties

• Melting Point: 84-85°C
• Boiling Point: 298.876 °C at 760 mmHg
• Flash Point: 134.556 °C
• Appearance: White to off-white powder
• Density: 1.454 g/cm³
• Vapor Pressure: 0.00123mmHg at 25°C
• Refractive Index: 1.573
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 12.00±0.70(Predicted)
• CAS DataBase Reference: (2-BROMO-PYRIDIN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: (2-BROMO-PYRIDIN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTER(116026-98-3)
• EPA Substance Registry System: (2-BROMO-PYRIDIN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTER(116026-98-3)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 116026-98-3(Hazardous Substances Data)

Usage

Chemical Properties

White solid

InChI:InChI=1/C10H13BrN2O2/c1-10(2,3)15-9(14)13-7-5-4-6-12-8(7)11/h4-6H,1-3H3,(H,13,14)

Upstream product

• 35905-85-2 2-bromonicotinic acid 
• 75-65-0 tert-butyl alcohol 
• 462-08-8 pyridin-3-ylamine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 39856-58-1 3-amino-2-bromopyridine 
• 7440-44-0 pyrographite 
• 1538-75-6 2,2-dimethylpropanoic anhydride 

Downstream Products

• 917868-24-7 tert-butyl (2-bromopyridin-3-yl)ethylcarbamate 
• 815631-72-2 [2-(4-fluoro-2-methyl-phenyl)-pyridin-3-yl]-carbamic acid tert-butyl ester 
• 1260092-57-6 {2-[6-(5-fluoro-2-methoxyphenyl)-4-hydroxy-6-methyl-4-trifluoromethylhept-1-ynyl]pyridin-3-yl}carbamic acid tert-butyl ester 
• 1060803-71-5 tert-butyl N-[2-(aminomethyl)pyridin-3-yl]carbamate 
• 116026-99-4 (2?formyl?pyridin?3?yl)?carbamic acid tert?butyl ester 
• 1195789-72-0 {7-[(4-fluoro-benzenesulfonyl)-methyl-amino]-6,7,8,9-tetrahydro-pyrido[2,3-b]indolizin-10-yl}-acetic acid ethyl ester 
• 1187081-31-7 {7-[(4-fluoro-benzenesulfonyl)-methyl-amino]-6,7,8,9-tetrahydro-pyrido[2,3-b]indolizin-10-yl}-acetic acid 
• 1187081-30-6 4-fluoro-N-methyl-N-(6,7,8,9-tetrahydro-pyrido[2,3-b]indolizin-7-yl)-benzenesulfonamide 
• 1432492-72-2 tert-butyl 2-(hydroxy(1-(3-(trifluoromethyl)phenyl)cyclobutyl)methyl)-pyridin-3-ylcarbamate 
• 872492-60-9 N-(2-bromopyridin-3-yl)-N-methylamine 
• 1393598-36-1 C₁₄H₁₃N₃O 
• 1393598-35-0 3-(4-fluorophenyl)-1-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one 
• 1393598-34-9 C₁₄H₁₃N₃O₂ 
• 1312606-11-3 2-(1-(6-amino-5-cyanopyrimidin-4-ylamino)ethyl)-N-methyl-3-phenyl-1,5-naphthyridine-4-carboxamide 

Relevant articles and documents

Synthesis method of 3-aminopyridine formaldehyde

The invention discloses a synthesis method of 3-aminopyridine formaldehyde, which comprises the following steps of: carrying out a cutius rearrangement reaction on 2-bromonicotinic acid serving as a raw material to obtain tert-butyl (2-bromopyridine-3-yl) carbamate, carrying out a Grignard reaction to obtain tert-butyl (2-formyl pyridine-3-yl) carbamate, and finally carrying out a hydrolysis reaction to obtain 3-aminopyridine formaldehyde. The synthesis method overcomes the defects of expensive raw materials, low yield, use of microwave reaction and other conditions, difficulty in amplification and the like in the existing synthesis process, and has the advantages of simple synthesis route, reasonable process selection, low raw material cost, simple and easily available raw materials, convenience in operation and post-treatment, high total yield, no use of highly toxic reagents, easiness in amplification, and realization of mass production.

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NOVEL TRPV3 MODULATORS

Disclosed herein are modulators of TRPV3 of formula (II): wherein G1, X1, X2, X3, X4, X5, G2, Ra, Rb, and u are as defined in the specification. Composition