119584-77-9 Usage
Uses
Used in Pharmaceutical Research and Development:
2,4-DIAMINO-6-FLUOROQUINAZOLINE is used as a chemical intermediate for the synthesis of pharmaceutical drugs, leveraging its unique structure to potentially enhance the properties of new drug candidates.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 2,4-DIAMINO-6-FLUOROQUINAZOLINE is used as a compound of interest for investigating its pharmacological properties, with the aim of discovering its potential therapeutic effects and applications in medicine.
The specific uses and potential effects of 2,4-DIAMINO-6-FLUOROQUINAZOLINE are still under investigation by researchers, indicating that its full range of applications may not yet be fully understood or realized. As research progresses, it is expected that the utility of 2,4-DIAMINO-6-FLUOROQUINAZOLINE in various pharmaceutical applications will become more apparent.
Check Digit Verification of cas no
The CAS Registry Mumber 119584-77-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,9,5,8 and 4 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 119584-77:
(8*1)+(7*1)+(6*9)+(5*5)+(4*8)+(3*4)+(2*7)+(1*7)=159
159 % 10 = 9
So 119584-77-9 is a valid CAS Registry Number.
InChI:InChI=1/C8H7FN4/c9-4-1-2-6-5(3-4)7(10)13-8(11)12-6/h1-3H,(H4,10,11,12,13)
119584-77-9Relevant academic research and scientific papers
SNAr reaction in aqueous medium in the presence of mixed organic and inorganic bases
Shelke, Nilesh B.,Ghorpade, Ramrao,Pratap, Ajay,Tak, Vijay,Acharya
, p. 31226 - 31230 (2015/04/22)
N-Arylation of amines with fluorobenzonitriles in aqueous medium is described. A mixture of N,N-diisopropylethyl amine and Na2CO3 (1:1) is found to achieve maximum conversion by refluxing for 3 hours in water. The product can be easily isolated by solvent extraction.
Direct Synthesis of 2,4-Diaminoquinazolines from 2-Fluorobenzonitriles
Hynes, John B.,Pathak, Alpana,Panos, Constantina H.,Okeke, Claudia C.
, p. 1173 - 1177 (2007/10/02)
In a search for new methods for preparing 2,4-diaminoquinazolines having a diversity of substituents in the benzenoid ring, it was found that the reaction of 2,6-difluorbenzonitrile with guanidine carbonate gave 2,4-diamino-5-fluoroquinazoline in excellent yield.Extension of this approach to other 2-fluorobenzonitriles, some of which were elaborated for the first time, showed that this reaction possesses considerable generality.The cyclization was sucessful even when electron donating groups were present at position six.Only in two cases where a primary or secondary amino group was also present ortho to the cyano group was this transformation unsucessful.
