1196119-50-2Relevant academic research and scientific papers
Diselenides and benzisoselenazolones as antiproliferative agents and glutathione-S-transferase inhibitors
Krasowska, Dorota,Iraci, Nunzio,Santi, Claudio,Drabowicz, Józef,Cieslak, Marcin,Ka?mierczak-Barańska, Julia,Palomba, Martina,Królewska-Golińska, Karolina,Magiera, Jakub,Sancineto, Luca
, (2019)
A series of variously functionalized selenium-containing compounds were purposely synthesized and evaluated against a panel of cancer cell lines. Most of the compounds showed an interesting cytotoxicity profile with compound 5 showing a potent activity on MCF7 cells. The ethyl amino derivative 5 acts synergistically with cis-platin and inhibits the GST enzyme with a potency that well correlates with the cytotoxicity observed in MCF7 cells. A computational analysis suggests a possible binding mode on the GST enzyme. As the main outcome of the present study, the ethyl amino derivative 5 emerged as a valid lead compound for further, future developments.
Synthesis and structure - activity correlation studies of secondary- and tertiary-amine-based glutathione peroxidase mimics
Bhabak, Krishna P.,Mugesh, Govindasamy
experimental part, p. 9846 - 9854 (2010/04/29)
In this study, a series of secondary- and tertiary-amino-substituted diaryl diselenides were synthesized and studied for their glutathione peroxidase (GPx) like antioxidant activities with H2O2, cumene hydroperoxide, or tBuOOH as sub
