1196474-64-2

Upstream product

• 3769-41-3 3-Benzyloxyphenol 
• 59142-68-6 2-bromo-4-fluorobenzaldehyde 

Downstream Products

• 1196474-65-3 4-(3-benzyloxy-phenoxy)-2-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)benzaldehyde 
• 1196475-08-7 ethyl 3-(6-(3-(benzyloxy)phenoxy)-1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-3-yl)propanoate 
• 1196473-86-5 3-(6-(3-(benzyloxy)phenoxy)-1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-3-yl)propanoic acid 
• 1196473-92-3 6-(3-(benzyloxy)phenoxy)-3-(3-hydroxypropyl)benzo[c][1,2]oxaborol-1(3H)-ol 
• 1196475-09-8 ethyl 3-(6-(3-(benzyloxy)phenoxy)-1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-3-yl)propanoate 
• 1196473-41-2 6-(3-hydroxy-phenoxy)-3H-benzo[c][1,2]oxaborol-1-ol 
• 1196473-40-1 6-(3-benzyloxy-phenoxy)-3H-benzo[c][1,2]oxaborol-1-ol 

Relevant academic research and scientific papers

Synthesis and SAR of novel benzoxaboroles as a new class of β-lactamase inhibitors

A new class of benzoxaborole β-lactamase inhibitors were designed and synthesized. 6-Aryloxy benzoxaborole 22 inhibited AmpC P99 and CMY-2 with K i values in the low nanomolar range. Compound 22 restored antibacterial activity of ceftazidime against Enterobacter cloacae P99 expressing AmpC, a class C β-lactamase enzyme. The SAR around the arylbenzoxaboroles, which included the influence of linker and substitutions was also established.

BORON-CONTAINING SMALL MOLECULES

This invention relates to, among other items, 6-substituted benzoxaborole compounds and their use for treating bacterial infections.

AMINO ALCOHOL DERIVATIVE, ADDITION SALT THEREOF, AND IMMUNOSUPPRESSANT

An amino alcohol derivative represented by the following general formula (1) (for example, (±)-2-amino-5-[4-(3-benzyloxyphenylthio)-2-chlorophenyl]-2-methylpentane-1-ol) exhibits strong immunosuppressive effect while causing less side effects:

AMINOPHOSPHONIC ACID DERIVATIVES, ADDITION SALTS THEREOF AND S1P RECEPTOR MODULATORS

Aminophosphonic acid derivatives (e.g., 2-amino-5-[4-(3-benzyloxyphenylthio)-2-chlorophenyl]-2-methylpentylphosphonate monoester) are represented by the following general formula (1) : and act as effective S1P receptor modulators while posing less side effects.

DIARYL ETHER DERIVATIVE, ADDITION SALT THEREOF, AND IMMUNOSUPPRESSANT

The present invention provides diaryl ether derivatives that exhibit significant immunosuppressive effects with less side effects. The diaryl derivatives of the present invention are represented by the following general formula (1): ???one example is 2-amino-2-[4-(3-benzyloxyphenoxy)-2-chlorophenyl)propyl-1,3-propanediol.