1196785-91-7Relevant academic research and scientific papers
An efficient, microwave-assisted, one-pot synthesis of indoles under Sonogashira conditions
Chen, Yu,Markina, Nataliya A.,Larock, Richard C.
experimental part, p. 8908 - 8915 (2009/12/08)
A microwave-assisted, one-pot, three-component coupling reaction for the synthesis of indoles has been developed. The reaction is carried out in two steps under standard Sonogashira coupling conditions from an N-substituted/N,N-disubstituted 2-iodoaniline and a terminal alkyne, followed by the addition of acetonitrile and an aryl iodide. A variety of polysubstituted indoles have been prepared in moderate to excellent yields using the present method.
