62167-04-8

Basic information

• Product Name: 2-((4-methoxyphenyl)ethynyl)-N,N-dimethylaniline
• Synonyms: 2-((4-methoxyphenyl)ethynyl)-N,N-dimethylaniline
• CAS NO: 62167-04-8
• Molecular Weight: 251.328
• Mol File: 62167-04-8.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: 2-((4-methoxyphenyl)ethynyl)-N,N-dimethylaniline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-((4-methoxyphenyl)ethynyl)-N,N-dimethylaniline(62167-04-8)
• EPA Substance Registry System: 2-((4-methoxyphenyl)ethynyl)-N,N-dimethylaniline(62167-04-8)

Safety Data

• Hazardous Substances Data: 62167-04-8(Hazardous Substances Data)

Upstream product

• 696-62-8 para-iodoanisole 
• 219605-52-4 2′-N,N-dimethylaminophenylacetylene 
• 219605-51-3 N,N-dimethyl-2-((trimethylsilyl)ethynyl)benzenamine 
• 698-02-2 N,N-dimethyl-o-iodoaniline 
• 768-60-5 4-methoxyphenylacetylen 

Downstream Products

• 1196785-91-7 ethyl 4-[2-(4-methoxyphenyl)-1-methylindol-3-yl]benzoate 
• 136672-24-7 (4-methoxyphenyl)(1-methyl-3-indolyl)methane 
• 6910-85-6 1-methyl-2-(4-methoxyphenyl)-3-phenyl-1H-indole 
• 61843-43-4 N-methyl-2-(4-methoxyphenyl)indole 
• 1185743-97-8 2-(4-methoxyphenyl)-1-methyl-3-(p-tolylsulfenyl)indole 
• 1618087-08-3 11-(4-methoxyphenyl)-5-methyl-6-phenyl-5H-indeno[1,2-c]quinoline 
• 1516898-82-0 2-(4-methoxyphenyl)-1methyl-3-(trifluoromethylthio)-1H-indole 
• 938375-09-8 2-(4-methoxyphenyl)-1-methyl-1H-indole-3-carbonitrile 
• 98647-17-7 (4-methoxyphenyl)(1-methyl-1H-indol-3-yl)methanone 
• 1445138-72-6 C₂₅H₂₁NO 
• 1445138-71-5 C₂₅H₂₁N 
• 1198116-16-3 3-methoxy-11-methyl-5,6-diphenyl-11H-benzo[a]carbazole 
• 1198116-18-5 3-fluoro-11-methyl-5,6-diphenyl-11H-benzo[a]carbazole 
• 1185743-96-7 2-(4-methoxyphenyl)-1-methyl-3-(phenylsulfenyl)indole 

Relevant articles and documents

Au-promoted Pd-catalyzed arylative cyclization of N,N-dimethyl-o-alkynylaniline with aryl iodides: Access to 2,3-diaryl indoles and mechanistic insight

We have developed a Au-promoted Pd-catalyzed cyclization/cross-coupling of N,N-dimethyl-o-alkynylaniline with aryl iododes to synthesize 2,3-diarylindoles under mild and base-free conditions. A related vinyl-Au species has been isolated through Au-promoted cyclization of N,N-dimethyl-o-alkynylaniline and structurally characterized. Further study on its reactivity suggests the vinyl-Au species might be out of catalytic cycle, and PhPd(OTf)(PPh3)2 is probably the reaction intermediate.

Synthesis of: N -alkyl-3-sulfonylindoles and N -alkyl-3-sulfanylindoles by cascade annulation of 2-alkynyl- N, N -dialkylanilines

An efficient and metal-free approach to N-alkyl-3-sulfonylindoles and N-alkyl-3-sulfanylindoles from 2-alkynyl-N,N-dialkylanilines has been developed. In the presence of iodine and tert-butylhydroperoxide (TBHP), a variety of 2-alkynyl-N,N-dialkylanilines underwent a cascade radical annulation to yield 3-arylsulfonylindoles. In contrast, 3-arylsulfanylindoles were conveniently prepared by iodine mediated electrophilic annulation reactions. The present protocol uses the economical and environmentally friendly I2-TBHP or I2 system, and potentially bioactive N-alkyl-3-sulfonylindoles and N-alkyl-3-sulfanylindoles with various functional groups were successfully synthesized in moderate to good yields.

CuBr-promoted tandem cyclization/trifluoromethylation of 2-alkynylanilines: Efficient synthesis of 3-trifluoromethylindoles

A new efficient strategy for the synthesis of 3-trifluoromethyl-indoles was developed through tandem cyclization/ trifluoromethylation of 2-alkynylanilines and Umemoto’s reagent under effect of CuBr. The reaction features the use of cheap copper salt, mil