1196908-63-0Relevant academic research and scientific papers
Synthesis and anticancer activity evaluation of naphthalene-substituted triazole spirodienones
Luo, Lan,Jia, Jing Jing,Zhong, Qiu,Zhong, Xue,Zheng, Shilong,Wang, Guangdi,He, Ling
, (2021)
Building on our previous work that discovered 1,2,4-triazole–spirodienone as a promising pharmacophore for anticancer activity, we have further diversified 1,2,4–triazole- spirodienone derivatives and synthesized a series of novel naphthalene-substituted
Highly efficient cyanoimidation of aldehydes
Yin, Ping,Wen-Bo, Ma.,Chen, Yue,Huang, Wen-Cal,Deng, Yong,He, Ling
supporting information; experimental part, p. 5482 - 5485 (2010/02/27)
"Chemical Equation Presented" Cyanoimidation of aldehydes using cyanamide as a nitrogen source and using NBS as an oxidant was achieved in high yields without the addition of a catalyst. The method has several advantages, Including mild conditions, simple workflow, and inexpensive reagents. The reaction proceeds in a one-pot manner, giving rise to the formation of intermolecular C-N and C-O bonds. Subsequently, the substituted W-cyanobenimidate products may also undergo a cyclization reaction to give 1,2,4-triazole derivatives in high yields.
