1196981-04-0Relevant articles and documents
Rhodium-Catalyzed Regioselective C7-Functionalization of N-Pivaloylindoles
Xu, Lanting,Zhang, Chao,He, Yupeng,Tan, Lushi,Ma, Dawei
, p. 321 - 325 (2016)
An efficient rhodium-catalyzed method for direct C-H functionalization at the C7 position of a wide range of indoles has been developed. Good to excellent yields of alkenylation products were observed with acrylates, styrenes, and vinyl phenyl sulfones, whereas the saturated alkylation products were obtained in good yield with α,β-unsaturated ketones. Both the N-pivaloyl directing group and the rhodium catalyst proved to be crucial for high regioselectivity and conversion.
A Direct Access to 7-Aminoindoles via Iridium-Catalyzed Mild C-H Amidation of N-Pivaloylindoles with Organic Azides
Kim, Youyoung,Park, Juhyeon,Chang, Sukbok
supporting information, p. 1892 - 1895 (2016/05/19)
Ir(III)-catalyzed regioselective direct C-7 amidation of indoles in reaction with organic azides has been developed. While its efficiency was varied by the choice of N-directing groups, N-pivaloylindoles were most effective in undergoing the desired amidation at room temperature over a broad range of substrates. The reaction was scalable, and deprotection of the chelation group was also facile.
Intermodular decarboxylative direct C-3 arylation of indoles with benzoic acids
Cornelia, Josep,Lu, Pengfel,Larrosa, Igor
supporting information; experimental part, p. 5506 - 5509 (2010/02/28)
"Chemical Equation Presented" A palladium catalyzed C-H activation of indoles and a silver catalyzed decarboxylative C-C activation of ortho substituted benzoic acids are synergistically combined to synthesize indoles arylated exclusively In the C-3 posit
