1196986-24-9

Basic information

• Product Name: 5-(4-fluorophenyl)-3-(3-methoxyphenyl)-1H-pyrazole
• Synonyms: 5-(4-fluorophenyl)-3-(3-methoxyphenyl)-1H-pyrazole
• CAS NO: 1196986-24-9
• Molecular Weight: 268.29
• Mol File: 1196986-24-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 5-(4-fluorophenyl)-3-(3-methoxyphenyl)-1H-pyrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-fluorophenyl)-3-(3-methoxyphenyl)-1H-pyrazole(1196986-24-9)
• EPA Substance Registry System: 5-(4-fluorophenyl)-3-(3-methoxyphenyl)-1H-pyrazole(1196986-24-9)

Safety Data

• Hazardous Substances Data: 1196986-24-9(Hazardous Substances Data)

Upstream product

• 591-31-1 3-methoxy-benzaldehyde 
• 108087-83-8 [(3-methoxyphenyl)methylidene]hydrazine 
• 403-42-9 1-(4-fluorophenyl)ethanone 
• 1431642-65-7 C₁₆H₁₃FO₃ 
• 403-43-0 4-fluorobenzoyl chloride 
• 586-37-8 1-(3-Methoxyphenyl)ethanone 

Relevant articles and documents

The diaza-Nazarov cyclization involving a 2,3-diaza-pentadienyl cation for the synthesis of polysubstituted pyrazoles

An unprecedented iodine-mediated diaza-Nazarov (DAN) type cyclization for the construction of substituted pyrazoles from easily available starting materials via an enamine-iminium ion intermediate is described. The oxidative cyclization worked under green conditions with remarkable regioselectivity. This one-pot, efficient and operationally simple three-component intramolecular regioselective DAN cyclization displayed a wide range of substrate scope. The dichotomy of reaction pathways has been explored with density functional theory in the gas phase and solution phase. Of the possible 1,5-, 1,6-, and 1,7-electrocyclizations, the DAN cyclization, i.e., the 1,5-pathway offers the lowest activation energy barrier supporting our experimental observations.