119702-49-7Relevant academic research and scientific papers
3,3-Diethoxypropyl-lithium: A Masked Lithium Propanal Homoenolate in Organic Synthesis
Barluenga, Jose,Fernandez, Jose R.,Rubiera, Covadonga,Yus, Miguel
, p. 3113 - 3118 (2007/10/02)
3,3-Diethoxypropyl-lithium is prepared by lithiation of the corresponding chlorinated precursor with lithium naphthalenide at -78 deg C; the reaction of this masked propanal homoenolate with different elctrophilic reagents CO, (CH2)7CO, PhCOMe, PhCH=NPh, PhCONEt2, PhCN, c-C6H11CN, 4-MeC6H4CN> leads to the corresponding mono- and bi-functionalized compounds.In the case of the reaction with aldehydes or ketones the prepared crude products are oxidized with m-chloroperbenzoic acid, yielding directly the γ-substituted butyrolactones.
