109481-23-4Relevant articles and documents
TRH mimetics: Differentiation of antiamnesic potency from antidepressant effect
Mazurov, Anatoly A.,Andronati, Sergei A.,Korotenko, Tamara I.,Sokolenko, Nikolai I.,Dyadenko, Alexei I.,Shapiro, Yury E.,Gorbatyuk, Vitalii Ya.,Voronina, Tatyana A.
, p. 2029 - 2040 (2007/10/03)
For the purpose of rational modification of the TRH molecule, we were pursuing an approach that consists of two steps: (1) 'obligatory' replacement of histidine with glutamine in TRH and (2) the application of conformational constraints for putative bioac