119718-07-9

Upstream product

• 119588-70-4 (2R,3S)-2-Amino-3-hydroxy-3-[(2S,4S,5R)-4-methyl-5-phenyl-3-(toluene-4-sulfonyl)-oxazolidin-2-yl]-propionic acid 
• 119588-68-0 (E)-3-[(2S,4S,5R)-4-Methyl-5-phenyl-3-(toluene-4-sulfonyl)-oxazolidin-2-yl]-propenal 
• 108591-33-9 N-((1R,2S)-1-hydroxy-1-phenylpropan-2-yl)-4-methylbenzene sulfonamide 
• 119588-78-2 (2S,4S,5R,4'R,5'S)-4-Methyl-2'-oxo-5-phenyl-3-(toluene-4-sulfonyl)-[2,5']bioxazolidinyl-4'-carboxylic acid methyl ester 

Downstream Products

• 185112-01-0 (2S,3S)-3-Hydroxy-3-[(2S,4S,5R)-4-methyl-5-phenyl-3-(toluene-4-sulfonyl)-oxazolidin-2-yl]-2-((R)-4-morpholin-4-yl-2-naphthalen-1-ylmethyl-4-oxo-butyrylamino)-propionic acid methyl ester 
• 185111-98-2 (2S,3S)-2-tert-Butoxycarbonylamino-3-hydroxy-3-[(2S,4S,5R)-4-methyl-5-phenyl-3-(toluene-4-sulfonyl)-oxazolidin-2-yl]-propionic acid methyl ester 
• 119588-72-6 (2S,3S)-2-Benzyloxycarbonylamino-3-hydroxy-3-[(2S,4S,5R)-4-methyl-5-phenyl-3-(toluene-4-sulfonyl)-oxazolidin-2-yl]-propionic acid ethyl ester 

Relevant academic research and scientific papers

Synthesis and renin inhibitory activity of novel angiotensinogen transition state analogues modified at the P2-histidine position

With the aim of finding new renin inhibitors with improved bioavailability properties, two angiotensinogen transition state analogues 1a and 1b, containing a novel unnatural amino acid at the P2 position, namely the (2R,3S)- and (2S,3S)-2-amino

ASYMMETRIC SYNTHESIS OF FUNCTIONALIZED α-AMINO-β-HYDROXY ACIDS VIA CHIRAL NOREPHEDRINE-DERIVED OXAZOLIDINES

Both anti and syn enantiomerically pure functionalized α-amino-β-hydroxy acids and derivatives were synthesized starting from norephedrine-derived oxazolidine (1).The key-steps of the synthesis were the nucleophilic epoxidation of (1) and the nucleophilic