119730-09-5Relevant academic research and scientific papers
Synthesis and heterocyclization of 2-{[2-(4-bromophenyl)-2-oxoethyl]sulfanyl}pyrimidin-4(3H)-ones
Frolova,Kim,Sharutin,Shal’Kova
, p. 96 - 98 (2016)
Alkylation of sodium 4(5)-alkyl-6-oxo-1,6-dihydropyrimidine-2-thiolates with 2-bromo-1-(4-bromophenyl)ethan-1-one afforded 2-{[2-(4-bromophenyl)-2-oxoethyl]sulfanyl}pyrimidin-4(3H)-ones. Analogous reaction with sodium 4-trifluoromethyl-6-oxo-1,6-dihydropyrimidine-2-thiolate gave a mixture of 2-{[2-(4-bromophenyl)-2-oxoethyl]sulfanyl}-4-(trifluoromethyl)pyrimidin-4(3H)-one and its intramolecular cyclization product, 3-(4-bromophenyl)-3-hydroxy-7-trifluoromethyl-2,3-dihydro[1,3]thiazolo[3,2-a]-pyrimidin-5-one.
Synthesis of pyridinylketones, and their cyclic derivatives produced from 6-methyl-2-thiouracil
Yavolovskii,Grishchuk,Rakipov,Ivanov,Stepanov,Kamalov
, p. 725 - 728 (2012/10/07)
A possibility to obtain pyrimidines, containing oxoalkyl moiety in 2 position of the ring from the available 6-methyl-2-thiouracil was shown.
The Eschenmoser coupling reaction under continuous-flow conditions
Singh, Sukhdeep,Michael Koehler,Schober, Andreas,Alexander Gross
supporting information; experimental part, p. 1164 - 1172 (2011/10/08)
The Eschenmoser coupling is a useful carbon-carbon bond forming reaction which has been used in various different synthesis strategies. The reaction proceeds smoothly if S-alkylated ternary thioamides or thiolactames are used. In the case of S-alkylated s
The Chemistry of Pyrimidinethiols. II. The Preparation and Reaction of Some 2-Arenecarbonylmethylthiopyrimidines
Hurst, Derek T.,Beaumont, Claire,Jones, Derek T. E.,Kingsley, Deborah A.,Partridge, Julian D.,Rutherford, Trevor J.
, p. 1209 - 1219 (2007/10/02)
A number of 2-arenecarbonylmethylthiopyrimidin-4(1H)-ones has been synthesized.Those having H, Me or Pr as a 6-substituent undergo ready sulfur extrusion on heating in diphenyl ether to give 2-(arenecarbonylmethylene)-2,3-dihydropyrimidin-4(1H)-ones, but
