1197335-53-7Relevant academic research and scientific papers
Synthesis and reactivity of 4-oxo-5-trimethylsilanyl derived α-amino acids
Reid, Caroline M.,Fanning, Kate N.,Fowler, Lindsay S.,Sutherland, Andrew
, p. 245 - 251 (2015/02/02)
A Lewis-acid promoted one-carbon homologation of an aspartic acid semialdehyde with trimethylsilyldiazomethane has led to the efficient synthesis of two silicon-containing α-amino acids. The use of trimethylaluminium or catalytic tin(II) chloride gave nov
Synthesis of fluorescent enone derived α-amino acids
Fowler, Lindsay S.,Ellis, David,Sutherland, Andrew
experimental part, p. 4309 - 4316 (2009/12/06)
The development of a facile and general method for the preparation of enone derived α-amino acids is described. The key step involves a Horner-Wadsworth-Emmons reaction between an aspartic acid derived β-keto phosphonate ester and a range of aldehydes resulting in the formation of highly functionalised α-amino acids in good yields. An efficient two-stage deprotection process using mild conditions was developed to give the parent α-amino acids. Application of this methodology has produced a novel fluorescent α-amino acid that has potential as a biological marker.
