1197347-89-9Relevant academic research and scientific papers
An efficient metal-free cascade process for the synthesis of 4-arylpyrimido[1,2-b]indazole-3-carbonitrile derivatives
Li, Lei,Xu, Hui,Dai, Lei,Xi, Junhua,Gao, Lingli,Rong, Liangce
, p. 5358 - 5365 (2017)
An efficient metal-free cascade reaction to synthesize novel pyrimido[1,2-b]indazole-3-carbonitrile derivatives was reported. The reaction starts from aromatic aldehydes, 1H-indazol-3-amine (4-chloro-1H-indazol-3-amine), and 3-(1H-indol-3-yl)-3-oxopropane
Multisubstituted indole-acrylonitrile hybrids as potential cytotoxic agents
Ke, Shaoyong,Yang, Ziwen,Zhang, Zhigang,Liang, Ying,Wang, Kaimei,Liu, Manli,Shi, Liqiao
, p. 1907 - 1911 (2014/04/17)
A series of multisubstituted indole-acrylonitrile hybrids were designed, synthesized and evaluated for their potential cytotoxic activities. The bio-evaluation results indicated that some of the target compounds (such as 3a, 3f, 3k, 3n) exhibited good to moderate cytotoxic effect on HepG2, BCG-823, BEL-7402, and HL-7702 cell lines. Especially, the compounds 3a and 3k also exhibited high cytotoxic activities (3a, 19.38 ± 3.38 μM; 3k, 15.43 ± 3.54 μM) against the BEL-7402 cell line resistant to Taxol (>25 μM) and 5-FU (>500 μM), which might be developed as novel lead scaffold for potential anticancer agents.
InCl3 mediated one-pot multicomponent synthesis, anti-microbial, antioxidant and anticancer evaluation of 3-pyranyl indole derivatives
Lakshmi, Neelakandan Vidhya,Thirumurugan, Prakasam,Noorulla,Perumal, Paramasivan.T.
scheme or table, p. 5054 - 5061 (2010/10/05)
A simple and convenient method for the one-pot three-component synthesis of 3-pyranyl indoles has been accomplished by tandem Knoevenagel-Michael reaction of 3-cyanoacetyl indole, various aromatic aldehydes and malononitrile catalyzed by InCl3 in ethanol under reflux conditions. The newly synthesized 3-pyranyl indoles were evaluated for anti-microbial, antioxidant, and anticancer activities. Some of the compounds showed good anticancer activity against MCF-7 breast cancer cell lines on comparison with of standard drug.
Regioselective three-component synthesis of indolylpyrazolo[3, 4-b]pyridines induced by microwave and under solvent-free conditions
Quiroga, Jairo,Trilleras, Jorge,Sanchez, Ana Isabel,Insuasty, Braulio,Abonia, Rodrigo,Nogueras, Manuel,Cobo, Justo
experimental part, p. 381 - 383 (2010/04/23)
New 4-(1H-indol-3-yl)-6-arylpyrazolo[3, 4-b]pyridines 7 have been prepared in a solvent-free three-component reaction induced by microwave from 5-aminopyrazole 1, benzaldehydes 2 and 3-indolyl-3-oxopropanenitrile 5. These compounds were also obtained by means of the reaction of aminopyrazole 1 with benzylidene-derivatives of 3-(1H-indol-3-yl)-3-oxopropanenitrile 6, prepared in the reaction of 3-(1H-indol-3-yl)-3-oxopropanenitrile and aldehydes. 2009 Bentham Science Publishers Ltd.
InCl3 mediated one-pot synthesis of indol-3-yl pyridine and 2,2′-bipyridine derivatives through multi-component reaction
Thirumurugan, Prakasam,Perumal, Paramasivan T.
experimental part, p. 7620 - 7629 (2009/12/04)
A simple protocol for the efficient preparation of 2-(1H-Indol-3-yl)-6-methoxy-4-aryl pyridine-3,5-dicarbonitrile and 6-methoxy-4-aryl-2,2′-bipyridine-5-carbonitrile derivatives has been achieved through one-pot multi-component reaction under reflux condi
