1197348-07-4Relevant academic research and scientific papers
Multisubstituted indole-acrylonitrile hybrids as potential cytotoxic agents
Ke, Shaoyong,Yang, Ziwen,Zhang, Zhigang,Liang, Ying,Wang, Kaimei,Liu, Manli,Shi, Liqiao
, p. 1907 - 1911 (2014/04/17)
A series of multisubstituted indole-acrylonitrile hybrids were designed, synthesized and evaluated for their potential cytotoxic activities. The bio-evaluation results indicated that some of the target compounds (such as 3a, 3f, 3k, 3n) exhibited good to moderate cytotoxic effect on HepG2, BCG-823, BEL-7402, and HL-7702 cell lines. Especially, the compounds 3a and 3k also exhibited high cytotoxic activities (3a, 19.38 ± 3.38 μM; 3k, 15.43 ± 3.54 μM) against the BEL-7402 cell line resistant to Taxol (>25 μM) and 5-FU (>500 μM), which might be developed as novel lead scaffold for potential anticancer agents.
Regioselective three-component synthesis of indolylpyrazolo[3, 4-b]pyridines induced by microwave and under solvent-free conditions
Quiroga, Jairo,Trilleras, Jorge,Sanchez, Ana Isabel,Insuasty, Braulio,Abonia, Rodrigo,Nogueras, Manuel,Cobo, Justo
experimental part, p. 381 - 383 (2010/04/23)
New 4-(1H-indol-3-yl)-6-arylpyrazolo[3, 4-b]pyridines 7 have been prepared in a solvent-free three-component reaction induced by microwave from 5-aminopyrazole 1, benzaldehydes 2 and 3-indolyl-3-oxopropanenitrile 5. These compounds were also obtained by means of the reaction of aminopyrazole 1 with benzylidene-derivatives of 3-(1H-indol-3-yl)-3-oxopropanenitrile 6, prepared in the reaction of 3-(1H-indol-3-yl)-3-oxopropanenitrile and aldehydes. 2009 Bentham Science Publishers Ltd.
