1197420-17-9

Basic information

• Product Name: (R)-1-cyclopropyl-2-(2-methoxy-4-nitrophenoxy)ethanol
• Synonyms: (R)-1-cyclopropyl-2-(2-methoxy-4-nitrophenoxy)ethanol
• CAS NO: 1197420-17-9
• Molecular Weight: 253.255
• Mol File: 1197420-17-9.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (R)-1-cyclopropyl-2-(2-methoxy-4-nitrophenoxy)ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-1-cyclopropyl-2-(2-methoxy-4-nitrophenoxy)ethanol(1197420-17-9)
• EPA Substance Registry System: (R)-1-cyclopropyl-2-(2-methoxy-4-nitrophenoxy)ethanol(1197420-17-9)

Safety Data

• Hazardous Substances Data: 1197420-17-9(Hazardous Substances Data)

Upstream product

• 765-43-5 Cyclopropyl methyl ketone 
• 69267-75-0 2-bromo-1-cyclopropylethan-1-one 
• 1197420-18-0 racemic 1-cyclopropyl-2-(2-methoxy-4-nitrophenoxy)ethanol 
• 1197420-16-8 1-cyclopropyl-2-(2-methoxy-4-nitrophenoxy)ethanone 

Downstream Products

• 1197420-19-1 (R)-2-(4-amino-2-methoxyphenoxy)-1-cyclopropylethanol 
• 1224171-79-2 (R)-tert-butyl (1-cyclopropyl-2-(2-methoxy-4-nitrophenoxy)ethoxy)dimethylsilane 
• 1197420-05-5 (R)-6-(4-chlorophenyl)-3-(4-(2-cyclopropyl-2-hydroxyethoxy)-3-methoxyphenyl)thieno[3,2-d]pyrimidin-4(3H)-one 
• 1197420-26-0 (R)-2-(4-(6-(4-chlorophenyl)-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl)-2-methoxyphenoxy)-1-cyclopropylethyl bis(2-(trimethylsilyl)ethyl)phosphate 
• 1197420-06-6 BMS₈₃₀₂₁₆ 

Relevant articles and documents

Identification of a nonbasic melanin hormone receptor 1 antagonist as an antiobesity clinical candidate

Identification of MCHR1 antagonists with a preclinical safety profile to support clinical evaluation as antiobesity agents has been a challenge. Our finding that a basic moiety is not required for MCHR1 antagonists to achieve high affinity allowed us to explore structures less prone to off-target activities such as hERG inhibition. We report the SAR evolution of hydroxylated thienopyrimidinone ethers culminating in the identification of 27 (BMS-819881), which entered obesity clinical trials as the phosphate ester prodrug 35 (BMS-830216).

PYRROLONE MELANIN CONCENTRATING HORMONE RECEPTOR-1 ANTAGONISTS

The present application provides compounds, including all stereoisomers, solvates, prodrugs and pharmaceutically acceptable forms thereof according to Formula I wherein R1, Formula Ia, R4, R5, Formula Ib, R3, R3a, W, D, R2a, R2b and R2c are defined herein. Additionally, the present application provides pharmaceutical compositions containing at least one compound according to Formula I and optionally at least one additional therapeutic agent. Finally, the present application provides methods for treating a patient suffering from an MCHR-1 modulated disease or disorder such as, for example, obesity, diabetes, depression, anxiety or intestinal inflammation, by administration of a therapeutically effective dose of a compound according to Formula I.