1197420-26-0

Basic information

• Product Name: (R)-2-(4-(6-(4-chlorophenyl)-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl)-2-methoxyphenoxy)-1-cyclopropylethyl bis(2-(trimethylsilyl)ethyl)phosphate
• Synonyms: (R)-2-(4-(6-(4-chlorophenyl)-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl)-2-methoxyphenoxy)-1-cyclopropylethyl bis(2-(trimethylsilyl)ethyl)phosphate
• CAS NO: 1197420-26-0
• Molecular Weight: 749.412
• Mol File: 1197420-26-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (R)-2-(4-(6-(4-chlorophenyl)-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl)-2-methoxyphenoxy)-1-cyclopropylethyl bis(2-(trimethylsilyl)ethyl)phosphate(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-2-(4-(6-(4-chlorophenyl)-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl)-2-methoxyphenoxy)-1-cyclopropylethyl bis(2-(trimethylsilyl)ethyl)phosphate(1197420-26-0)
• EPA Substance Registry System: (R)-2-(4-(6-(4-chlorophenyl)-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl)-2-methoxyphenoxy)-1-cyclopropylethyl bis(2-(trimethylsilyl)ethyl)phosphate(1197420-26-0)

Safety Data

• Hazardous Substances Data: 1197420-26-0(Hazardous Substances Data)

Upstream product

• 1197420-05-5 (R)-6-(4-chlorophenyl)-3-(4-(2-cyclopropyl-2-hydroxyethoxy)-3-methoxyphenyl)thieno[3,2-d]pyrimidin-4(3H)-one 
• 121373-20-4 N,N-Diisopropyl-bis<2-(trimethylsilyl)ethyl>phosphoramidite 
• 69267-75-0 2-bromo-1-cyclopropylethan-1-one 
• 765-43-5 Cyclopropyl methyl ketone 
• 1197420-16-8 1-cyclopropyl-2-(2-methoxy-4-nitrophenoxy)ethanone 
• 1197420-18-0 racemic 1-cyclopropyl-2-(2-methoxy-4-nitrophenoxy)ethanol 
• 1197420-17-9 (R)-1-cyclopropyl-2-(2-methoxy-4-nitrophenoxy)ethanol 
• 1197420-19-1 (R)-2-(4-amino-2-methoxyphenoxy)-1-cyclopropylethanol 
• 515141-52-3 methyl 5-(4-chlorophenyl)-3-{[(1E)-(dimethylamino)methylidene]amino}-2-thiophenecarboxylate 
• 91076-93-6 methyl 3-amino-5-(4-chlorophenyl)-2-thiophenecarboxylate 
• 2916-68-9 2-(Trimethylsilyl)ethanol 

Downstream Products

• 1197420-05-5 (R)-6-(4-chlorophenyl)-3-(4-(2-cyclopropyl-2-hydroxyethoxy)-3-methoxyphenyl)thieno[3,2-d]pyrimidin-4(3H)-one 
• 1197420-06-6 BMS₈₃₀₂₁₆ 

Relevant articles and documents

Identification of a nonbasic melanin hormone receptor 1 antagonist as an antiobesity clinical candidate

Identification of MCHR1 antagonists with a preclinical safety profile to support clinical evaluation as antiobesity agents has been a challenge. Our finding that a basic moiety is not required for MCHR1 antagonists to achieve high affinity allowed us to explore structures less prone to off-target activities such as hERG inhibition. We report the SAR evolution of hydroxylated thienopyrimidinone ethers culminating in the identification of 27 (BMS-819881), which entered obesity clinical trials as the phosphate ester prodrug 35 (BMS-830216).