119754-15-3

Upstream product

• 50-00-0 formaldehyd 
• 14235-81-5 4-Ethynylaniline 
• 74-88-4 methyl iodide 
• 1233957-30-6 N-methyl-4-[(trimethylsilyl)ethynyl]aniline 
• 100-61-8 N-methylaniline 
• 60577-34-6 p-iodo-N-methylaniline 

Downstream Products

• 946052-55-7 4-(1-(4-iodophenyl)-1H-1,2,3-triazol-4-yl)-N-methylbenzenamine 
• 1239440-04-0 4-(5-bromo-1H-indol-2-yl)-N-methylbenzenamine 
• 1374418-19-5 C₂₃H₁₆BrN 
• 1374418-25-3 C₃₄H₂₇N₃O₅ 
• 1313757-53-7 C₁₃H₁₅NO₂ 
• 128971-10-8 {4-[4-(2,5-Bis-trifluoromethyl-phenyl)-buta-1,3-diynyl]-phenyl}-methyl-amine 
• 128971-19-7 {4-[4-(3,5-Bis-trifluoromethyl-phenyl)-buta-1,3-diynyl]-phenyl}-methyl-amine 
• 17573-94-3 4-ethynyl-N,N-dimethylaniline 
• 946052-57-9 N-methyl-4-[1-(4-tributylstannylphenyl)-1H-1,2,3-triazol-4-yl]benzenamine 

Relevant academic research and scientific papers

Photoinduced Hydroarylation and Cyclization of Alkenes with Luminescent Platinum(II) Complexes

Photoinduced hydroarylation of alkenes is an appealing synthetic strategy for arene functionalization. Herein, we demonstrated that aryl radicals generated from electron-deficient aryl chlorides/bromides could be trapped by an array of terminal/internal aryl alkenes in the presence of [Pt(O^N^C^N)] under visible-light (410 nm) irradiation, affording anti-Markovnikov hydroarylated compounds in up to 95 % yield. Besides, a protocol for [Pt(O^N^C^N)]-catalyzed intramolecular photocyclization of acrylanilides to give structurally diverse 3,4-dihydroquinolinones has been developed.

Fluorescent nucleosides with 'on-off' switching function, pH-responsive fluorescent uridine derivatives

We synthesized various pH-responsive fluorescent deoxyuridine derivatives (1a-g). These fluorescent nucleosides exhibited distinctive fluorescence at 470-600 nm in aqueous solvents containing methanol only at acidic to neutral pH values. In particular, 1f exhibited strong fluorescence only at pH range of 3.1-7.2 with a pKa of 6.1. Such pH-sensitive fluorescent nucleosides can be used as 'on-off' fluorescence switch for monitoring pH change in biological systems, particularly for cancer cell detection.

Synthesis and characterization of novel phenylindoles as potential probes for imaging of β-amyloid plaques in the brain

We synthesized a novel series of phenylindole (PI) derivatives and evaluated their biological activities as probes for imaging Aβ plaques in vivo. The affinity for Aβ plaques was assessed by an in vitro-binding assay using pre-formed synthetic Aβ aggregates. 2-Phenyl-1H-indole (2-PI) derivatives showed high affinity for Aβ42 aggregates with Ki values ranging from 4 to 32 nM. 2-PI derivatives clearly stained Aβ plaques in an animal model of AD. In biodistribution experiments using normal mice, 2-PI derivatives displayed sufficient uptake for imaging, ranging from 1.1% to 2.6% ID/g. Although additional modifications are necessary to improve uptake by and clearance from the brain, 2-PI derivatives may be useful as a backbone structure to develop novel Aβ imaging agents.

Quick assembly of 1,4-diphenyltriazoles as probes targeting β-amyloid aggregates in Alzheimer's disease

Accumulation of β-amyloid aggregates (Aβ) in the brain is linked to the pathogenesis of Alzheimer's disease (AD). We report a novel approach for producing 1,4-diphenyltriazoles as probes for targeting Aβ aggregates in the brain. The imaging probes, a seri

Synthesis of Some Substituted Dimethyl and Diethyl 4-(Phenylethynyl)-2,6-pyridinedicarboxylates

Substituted dimethyl and diethyl 4-(phenylethynyl)-2,6-pyridinedicarboxylates were prepared by coupling reactions between dialkyl 4-halo-2,6-pyridinedicarboxylates and terminal arylacetylenes in the presence of an organopalladium catalyst and copper(I) iodide in a suitable solvent system.The terminal acetylenes needed in this work were synthesized from the corresponding aryl halides using either (trimethylsilyl)acetylene or 2-methyl-3-butyn-2-ol followed by deprotection of the triple bond, depending on the nature of the compound in question.