1233957-30-6Relevant articles and documents
Design of "click" Fluorescent Labeled 2′-deoxyuridines via C5-[4-(2-Propynyl(methyl)amino)]phenyl Acetylene as a Universal Linker: Synthesis, Photophysical Properties, and Interaction with BSA
Bag, Subhendu Sekhar,Gogoi, Hiranya
, p. 7606 - 7621 (2018)
Microenvironment-sensitive fluorescent nucleosides present attractive advantages over single-emitting dyes for sensing inter-biomolecular interactions involving DNA. Herein, we report the rational design and synthesis of triazolyl push-pull fluorophore-la
Fluorescent nucleosides with 'on-off' switching function, pH-responsive fluorescent uridine derivatives
Saito, Yoshio,Miyamoto, Shigenori,Suzuki, Azusa,Matsumoto, Katsuhiko,Ishihara, Tsutomu,Saito, Isao
scheme or table, p. 2753 - 2756 (2012/05/19)
We synthesized various pH-responsive fluorescent deoxyuridine derivatives (1a-g). These fluorescent nucleosides exhibited distinctive fluorescence at 470-600 nm in aqueous solvents containing methanol only at acidic to neutral pH values. In particular, 1f exhibited strong fluorescence only at pH range of 3.1-7.2 with a pKa of 6.1. Such pH-sensitive fluorescent nucleosides can be used as 'on-off' fluorescence switch for monitoring pH change in biological systems, particularly for cancer cell detection.