119768-48-8Relevant articles and documents
o-Boronato- and o-Trifluoroborato - Phosphonium Salts Supported by L-α-Amino Acid Side Chain
Bernard, Julie,Malacea-Kabbara, Raluca,Clemente, Gon?alo S.,Burke, Benjamin P.,Eymin, Marie-Jo?lle,Archibald, Stephen J.,Jugé, Sylvain
, p. 4289 - 4298 (2015)
(Figure Presented) The synthesis of o-boronato- and o-trifluoroborato-phosphonium salts supported by the l-amino acid side chain is described. The synthesis of these new class of amino acid derivatives was achieved by stereoselective quaternization of o-(
VERSATILE AND STEREOSPECIFIC SYNTHESIS OF GAMMA,DELTA -UNSATURATED AMINO ACIDS BY WITTIG REACTION
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Page/Page column 39; 40, (2013/03/28)
The present invention relates to γ,δ-unsaturated a-amino acids of general formula (I). The present invention also provides a versatile process for the stereospecific synthesis of said compounds of formula (I), involving a Wittig reaction. The present invention also relates to intermediate products of general formulae (II) and (III), as shown below, which are involved in the synthesis of compounds (I).
NOVEL GAMMA-LACTAMS AS BETA-SECRETASE INHIBITORS
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Page 43; 113, (2008/06/13)
There is provided a series of novel substituted gamma-lactams of Formula (I) wherein R1, R2, R3, R4 and R5 are defined herein, their pharmaceutical compositions and methods of use. These novel compounds inhibit the processing of amyloid precursor protein (APP) by β-secretase and, more specifically, inhibit the production of aβ-peptide. The present invention is directed to compounds useful in the treatment of neurological disorders related to β-amyloid production, such as Alzheimer's disease and other conditions affected by anti-amyloid activity.