119770-46-6

Upstream product

• 1571-08-0 methyl 4-formylbenzoate 
• 106918-31-4 1-methoxy-2-(4-carbomethoxyphenyl)ethylene 
• 119770-40-0 5-(p-carbomethoxyphenyl)-1-phthalimido-3-penten-2-one 
• 106918-32-5 4-carbomethoxyphenylacetaldehyde 
• 96056-26-7 2-[2-oxo-3-(triphenyl-λ⁵-phosphanylidene)propyl]-1H-isoindole-1,3(2H)-dione 
• 119770-44-4 5-(p-carbomethoxyphenyl)-4-methyl-1-phthalimidopentan-2-one 

Downstream Products

• 119770-48-8 1-amino-5-(p-carbomethoxyphenyl)-4-methyl-2-pentanone oxime 
• 119787-36-9 (6R,S)-11-deaza-10-methyltetrahydrohomofolate 
• 119770-55-7 11-deaza-10-methylhomofolic acid 
• 119770-57-9 11-deaza-10-methyl-7,8-dihydrohomofolate 
• 119770-50-2 1-<(2-amino-4-hydroxy-5-nitropyrimidin-6-yl)amino>-5-(p-carbomethoxyphenyl)-4-methyl-2-pentanone oxime 
• 119770-52-4 1-<(2-amino-4-hydroxy-5-nitropyrimidin-6-yl)amino>-4-methyl-5-(p-carbomethoxyphenyl)pentan-2-one 
• 119770-53-5 11-deaza-10-methylhomopteroic acid 

Relevant academic research and scientific papers

Folate analogues. 31. Synthesis of the reduced derivatives of 11-deazahomofolic acid, 10-methyl-11-deazahomofolic acid, and their evaluation as inhibitors of glycinamide ribonucleotide formyltransferase

The Boon-Leigh procedure, involving condensation of a 6-chloro-5-nitropyrimidine (22) with an α-amino ketone (20 or 21) followed by reduction of the nitro group, cyclization, and L-glutamylation, led to the formation of 11-deazahomofolate (29) and its 10-