96056-26-7Relevant academic research and scientific papers
Ionic liquid-catalyzed and microwave-assisted syntheses of pyrrolizine-and indolizinedione derivatives
Sakhautdinov, I. M.,Batyrshin, I. R.,Sergeeva, N. A.,Galin, F. Z.,Yunusov, M. S.
, p. 788 - 792,5 (2020/08/31)
3H-Pyrrolo[2,1-a]isoindole-2,5-diones and isoindolo[2,1-a]quinoline-5,11- diones were synthesized by intramolecular cyclization of N-[2-oxo-3-(triphenyl- λ5-phosphanylidene)propyl]-and N-[2-(triphenyl- λ5-phosphanylidene)acetyl]phthalimides, respectively, in the presence of ionic liquid ([bmim][BF4], 10 mol %) as catalyst or under microwave irradiation.
Synthesis and evaluation of ketophosph(on)ates as β-lactamase inhibitors
Perumal, Senthil K.,Pratt
, p. 4778 - 4785 (2007/10/03)
A series of amidoketophosph(on)ates of general structure PhCH 2OCONHCH(R)COCHR′(CH2)n(O)P-(O 2-)(O)R″ (R = H, CH3; R′ = H, CH3; n = 0, 1; R″ = H, CH3, Et, Ph) have bee
Diels-Alder reactivity of 4-aryl-1-phthalimido-2-siloxy-1,3-butadienes
Caballero, Esther,Alonso, Dulce,Peláez, Rafael,álvarez, Concepción,Puebla, Pilar,Sanz, Francisca,Medarde, Manuel,Tomé, Fernando
, p. 6871 - 6878 (2007/10/03)
The reaction of (1Z,3E) and (1E,3E) 4-aryl-1-phthalimido-2-trialkylsiloxy- 1,3-butadienes with maleimides and quinones has been studied. The observed exo-stereospecifity can be attributed to the simultaneous presence of the phthalimido and aryl groups, which produce strong hindrance during the endo approach.
1-Phthalimido-4-(3-indolyl)-2-siloxy-1,3-butadienes: Synthesis and Diels-Alder reactivity
Caballero, Esther,Alonso, Dulce,Peláez, Rafael,Alvarez, Concepción,Puebla, Pilar,Sanz, Francisca,Medarde, Manuel,Tomé, Fernando
, p. 1631 - 1634 (2007/10/03)
New 1-phthalimido-4-(3-indolyl)-2-trialkylsiloxy-1,3-butadienes were easily prepared from 1,3-dichloropropanone and their configurations were established from NMR data. Their Diels-Alder reactivity with different maleimides and quinones was studied, high yields of the exo cycloadducts being obtained, as confirmed by X-ray diffraction studies.
Synthesis of Pyrrolizidinediones from Cyclic N,N-Diacylamino Acids
Bestmann, Hans Juergen,Moenius, Thomas,Soliman, Fouad
, p. 1527 - 1528 (2007/10/02)
Cyclic N,N-diacylamino acids can be converted by reaction with N-phenylketeniminylidenetriphenylphosphorane into pyrrolizidinediones.
Folate Analogues. 24. Syntheses of the Antitumor Agents 10-Deazaaminopterin (10-DAAM) and 10-Ethyl-10-deazaaminopterin (10-EDAAM)
Nair, M. G.
, p. 1879 - 1884 (2007/10/02)
Methods have been developed for the chemical synthesis of two recently described potent antitumor agents.They are 10-deazaaminopterin (10-DAAM) (2) and 10-ethyl-10-deazaaminopterin (10-EDAAM) (3).The methods described in this paper have general applicability for the synthesis of a variety of hitherto difficulty accessible 10-substituted-10-deazafolic acids and analogues.Reaction of methyl p-formylbenzoate (7) with the Wittig reagent 6 derived from N-(3-bromo-2-oxopropyl)phtalimide (5) and triphenylphosphine gave the common intermediate 8, which was used for the synthesis of both 2 and 3.This enone was reduced with Zn/HOAc to 15 and was used for the synthesis of 2.Alternately 8 was reacted with ethylmagnesium bromide in the presence of cuprous bromide to obtain the conjugate addition product 16.Both 15 and 16 were converted to the masked α-amino ketones 20 and 21 reacted with 6-chloro-2,4-diamino-5-nitropyrimidine to obtain 22 and 23.These pyrimidine intermediates were subsequently elaborated to the pteroic acid analogues 26 and 27 by multistep procedures previously described from this laboratory.The target compounds 2 and 3 were prepared from 26 and 27 by standard coupling procedures involving isobutyl chloroformate and diethyl L-glutamate.
