1197965-64-2Relevant academic research and scientific papers
Synthesis, characterization and antimicrobial activity of substituted 3-(phthalazine-1-ylamino)alkanoic acid containing imidoxy moiety
Salvi, Vijay Kumar,Pemawat, Gangotri,Bapna, Archita,Talesara
experimental part, p. 491 - 497 (2010/06/16)
Hydrozinolysis of phthalyl derivatives of amino acid 1a-c afforded [(4-oxo-3,4-dihydrophthalazine-1-yl)amino]substituted acetic acid 2a-c, which on reaction with POCl3/PCl5 gave [(4-chlorophthalazine-1-yl) amino]substituted acetic acid 3a-c. This when condensed with N-hydroxyphthalimide/N-hydroxysuccinimide 4a-b yielded phthalimido or succinimido-2-({4-phthalazine-1-yl}amino)substituted acetic acid 5a-f. Condensation of compounds 2a-c with ω-bromoalkoxyphthalimide 6a-b furnished the corresponding 2-[(3-{2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl) oxy]ethyl}-4-oxo-3,4-dihydrophthalazine-1-yl)amino]substituted acetic acid 7a-f. All the compounds were screened for antimicrobial activities.
