119798-08-2

Basic information

• Product Name: BOC4-SPER-CO2H
• Synonyms: N-ALPHA-N-DELTA-BIS-BOC-N-ALPHA-N-DELTA-BIS(3-BOC-AMINOPROPYL)-L-ORNITHINE;TETRA-BOC-SPERMINE-5-CARBOXYLIC ACID;BOC4-SPER-CO2H
• CAS NO: 119798-08-2
• Molecular Formula: C₃₁H₅₈N₄O₁₀
• Molecular Weight: 646.81
• Mol File: 119798-08-2.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 737.1±60.0 °C(Predicted)
• Appearance: /
• Density: 1.112±0.06 g/cm3(Predicted)
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
• PKA: 3.95±0.21(Predicted)
• Stability: Hygroscopic
• CAS DataBase Reference: BOC4-SPER-CO2H(CAS DataBase Reference)
• NIST Chemistry Reference: BOC4-SPER-CO2H(119798-08-2)
• EPA Substance Registry System: BOC4-SPER-CO2H(119798-08-2)

Safety Data

• Hazardous Substances Data: 119798-08-2(Hazardous Substances Data)

Usage

Uses

tetra-Boc-spermine-5-carboxylic acid (cas# 119798-08-2) is a spermidine (S680400) derivative used in nucleic acid transfer reactions, and in the synthesis of degradable multivalent cationic lipids with disulfide-bond spacers for gene delivery.

Upstream product

• 3184-13-2 L-ornithine hydrochloride 
• 119798-07-1 N_α,N_δ-bis(2-cyanoethyl)-L-ornithine 
• 124076-28-4 N_α,N_δ-bis(3-aminopropyl)-L-ornithine 
• 58632-95-4 2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 1323443-65-7 {(S)-1-[2-(2-{(3,4-di(oleyloxy)benzoyl)amino}-ethyldisulfanyl)-ethylcarbamoyl]-4-[tert-butoxycarbonyl-(3-tert-butoxycarbonylaminopropyl)-amino]-butyl}-(3-tert-butoxycarbonylamino-propyl)-carbamic acid tert-butyl ester 

Relevant articles and documents

A columnar phase of dendritic lipid-based cationic liposome-DNA complexes for gene delivery: Hexagonally ordered cylindrical micelles embedded in a DNA honeycomb lattice

Gene therapy holds great promise as a future approach to fighting disease and is explored in worldwide clinical trials. Cationic liposome (CL)-DNA complexes are a prevalent nonviral delivery vector, but their efficiency requires improvement and the unders

A highly efficient approach for the synthesis of cationic lipid DOSPA

A highly efficient strategy has been developed for the synthesis of the cationic lipid, N-[2-({2,5-bis[(3-aminopropyl)amino]-1-oxopentyl}amino)ethyl]-N, N-dimethyl-2,3-bis[(1-oxo-9-octadecenyl)oxy] salt with hydrogen chloride (DOSPA). It involves the linkage of a cationic head group and a hydrophobic moiety in the presence of the standard coupling reagents. Georg Thieme Verlag Stuttgart.