119798-08-2

Usage

Uses

Used in Gene Delivery:
BOC4-SPER-CO2H is used as a key intermediate in the synthesis of degradable multivalent cationic lipids with disulfide-bond spacers. These lipids are essential for the development of efficient gene delivery systems, as they enable the safe and targeted delivery of genetic material into cells.
Used in Nucleic Acid Transfer Reactions:
BOC4-SPER-CO2H is utilized as a spermidine derivative in nucleic acid transfer reactions, which are vital for the manipulation and analysis of nucleic acids, such as DNA and RNA. Its unique structure allows for the formation of stable complexes with nucleic acids, facilitating their transfer and subsequent applications in research and therapeutics.

Upstream product

• 3184-13-2 L-ornithine hydrochloride 
• 119798-07-1 N_α,N_δ-bis(2-cyanoethyl)-L-ornithine 
• 124076-28-4 N_α,N_δ-bis(3-aminopropyl)-L-ornithine 
• 58632-95-4 2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 1323443-65-7 {(S)-1-[2-(2-{(3,4-di(oleyloxy)benzoyl)amino}-ethyldisulfanyl)-ethylcarbamoyl]-4-[tert-butoxycarbonyl-(3-tert-butoxycarbonylaminopropyl)-amino]-butyl}-(3-tert-butoxycarbonylamino-propyl)-carbamic acid tert-butyl ester 

Relevant academic research and scientific papers

A columnar phase of dendritic lipid-based cationic liposome-DNA complexes for gene delivery: Hexagonally ordered cylindrical micelles embedded in a DNA honeycomb lattice

Gene therapy holds great promise as a future approach to fighting disease and is explored in worldwide clinical trials. Cationic liposome (CL)-DNA complexes are a prevalent nonviral delivery vector, but their efficiency requires improvement and the unders

Precision templating with DNA of a virus-like particle with peptide nanostructures

We report here the preparation of filamentous virus-like particles by the encapsulation of a linear or circular double-stranded DNA template with preassembled mushroom-shaped nanostructures having a positively charged domain. These nanostructures mimic the capsid proteins of natural filamentous viruses and are formed by self-assembly of coiled-coil peptides conjugated at opposite termini with cationic segments and poly(ethylene glycol) (PEG) chains. We found that a high molecular weight of PEG segments was critical for the formation of monodisperse and uniformly shaped filamentous complexes. It is proposed that electrostatic attachment of the nanostructures with sufficiently long PEG segments generates steric forces that increase the rigidity of the neutralized DNA template. This stiffening counterbalances the natural tendency of the DNA template to condense into toroids or buckle multiple times. The control achieved over both shape and dimensions of the particles offers a strategy to create one-dimensional supramolecular nanostructures of defined length containing nucleic acids.

A highly efficient approach for the synthesis of cationic lipid DOSPA

A highly efficient strategy has been developed for the synthesis of the cationic lipid, N-[2-({2,5-bis[(3-aminopropyl)amino]-1-oxopentyl}amino)ethyl]-N, N-dimethyl-2,3-bis[(1-oxo-9-octadecenyl)oxy] salt with hydrogen chloride (DOSPA). It involves the linkage of a cationic head group and a hydrophobic moiety in the presence of the standard coupling reagents. Georg Thieme Verlag Stuttgart.