1198-83-0

Basic information

• Product Name: 2-methylsulfanyl-7H-purin-6-amine
• Synonyms: 2-methylsulfanyl-7H-purin-6-amine;1H-Purin-6-amine, 2-(methylthio)-;2-(Methylthio)-7H-purin-6-aMine;2-(Methylthio)-9H-purin-6-amine;2-Methylthioadenine
• CAS NO: 1198-83-0
• Molecular Formula: C₆H₇N₅S
• Molecular Weight: 181.2183
• Mol File: 1198-83-0.mol

Chemical Properties

• Boiling Point: 628.2 °C at 760 mmHg
• Flash Point: 333.7 °C
• Appearance: /
• Density: 1.55 g/cm³
• Vapor Pressure: 6.74E-05mmHg at 25°C
• Refractive Index: 1.892
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• CAS DataBase Reference: 2-methylsulfanyl-7H-purin-6-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methylsulfanyl-7H-purin-6-amine(1198-83-0)
• EPA Substance Registry System: 2-methylsulfanyl-7H-purin-6-amine(1198-83-0)

Safety Data

• Hazardous Substances Data: 1198-83-0(Hazardous Substances Data)

Usage

Uses

Used in Medicinal Chemistry:
2-methylsulfanyl-7H-purin-6-amine is used as a research compound for exploring its potential biological activities and pharmacological properties. Its unique structure allows it to be a valuable tool in the development of new drugs and therapeutic agents.
Used in Drug Development:
In the pharmaceutical industry, 2-methylsulfanyl-7H-purin-6-amine is used as a lead compound for the design and synthesis of novel therapeutic agents. Its potential applications may include the treatment of various diseases and conditions, given its interaction with biological targets and systems.
Used in Biochemical Research:
2-methylsulfanyl-7H-purin-6-amine serves as a subject of study in biochemical research to understand its interactions with enzymes, receptors, and other biomolecules. This knowledge can contribute to the advancement of our understanding of biological processes and the development of targeted therapies.

InChI:InChI=1/C6H7N5S/c1-12-6-10-4(7)3-5(11-6)9-2-8-3/h2-3H,1H3,(H2,7,8,9,10,11)

Upstream product

• 353-43-5 boron dimethyl-trifluoro sulphide 
• 1839-18-5 6-Amino-2-chlorpurin 
• 52222-43-2 2-(methylthio)-5-nitrosopyrimidine-4,6-diamine 
• 1431-40-9 2-methylsulfanyl-pyrimidine-4,5,6-triamine 
• 1005-39-6 4,6-diamino-2-methylthiopyrimidine 
• 77287-34-4 formamide 
• 98197-66-1 N-(4,6-diamino-2-methylsulfanyl-pyrimidin-5-yl)-thioformamide 
• 64-18-6 formic acid 

Downstream Products

• 4105-39-9 2-(methylthio)adenosine 
• 3373-53-3 isoguanine 
• 7357-53-1 2-methanesulfonyl-7⁽⁹⁾H-purin-6-ylamine 
• 73-24-5 7H-purin-6-ylamine 
• 62700-65-6 2-Methylsulfanyl-9H-purin-6-ylamine; hydrochloride 
• 445417-53-8 N-[[9-(2'-O-tert-butyldimethylsilyl-5'-O-(4,4'-dimethoxytrityl)-β-D-ribofuranosyl)-2-(methylthio)purin-6-yl]carbamoyl]-O-tert-butyldimethylsilyl-L-threonine 2-(4-nitrophenyl)ethyl ester 
• 445417-52-7 N-[[9-(5'-O-(4,4'-dimethoxytrityl)-β-D-ribofuranosyl)-2-(methylthio)purin-6-yl]carbamoyl]-O-tert-butyldimethylsilyl-L-threonine 2-(4-nitrophenyl)ethyl ester 
• 445417-50-5 N-[[9-(2',3',5'-tri-O-acetyl-β-D-ribofuranosyl)-2-(methylthio)purin-6-yl]carbamoyl]-O-tert-butyldimethylsilyl-L-threonine 2-(4-nitrophenyl)ethyl ester 
• 445417-51-6 N-[[9-(β-D-ribofuranosyl)-2-(methylthio)purin-6-yl]carbamoyl]-O-tert-butyldimethylsilyl-L-threonine 2-(4-nitrophenyl)ethyl ester 
• 445417-49-2 phenyl N-[9-(2',3',5'-tri-O-acetyl-β-D-ribofuranosyl)-2-(methylthio)purin-6-yl]carbamate 
• 51549-17-8 2',3',5'-tri-O-benzoyl-2-(methylthio)adenosine 

Relevant articles and documents

BF3·SMe2 for Thiomethylation, Nitro Reduction and Tandem Reduction/SMe Insertion of Nitrogen Heterocycles

Herein, a general, solvent-free and straightforward thiomethylation of electron deficient heterocycles using BF3·SMe2 as a dual thiomethyl source and Lewis acidic activator is presented. A range of heterocycles including pyrimidine, pyrazine, pyridazine, thiazole and purine derivatives were successfully substituted using this method. An unexpected reductive property of BF3·SMe2 towards nitropyridines was also discovered including an intriguing tandem reduction/SMe insertion process in certain substrates. Notable features of the present work include its convenience and use of a non-malodorous reagent while the discovery of novel chemical transformations using BF3·SMe2 provides fundamental new insights into the reactivity of this commonly employed reagent.