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4-(oxiran-2-ylmethoxy)-9-(oxiran-2-ylmethyl)-9H-carbazole is a chemical compound that serves as an intermediate in the synthesis of various pharmaceutical compounds.

1198090-71-9

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1198090-71-9 Usage

Uses

Used in Pharmaceutical Industry:
4-(oxiran-2-ylmethoxy)-9-(oxiran-2-ylmethyl)-9H-carbazole is used as an intermediate in the synthesis of N-2-Hydroxy-3-[[2-(methoxyphenoxy)ethyl]amine Carvedilol (Carvedilol EP Impurity A) (H946145), which is an impurity from the process of Carvedilol (C184625). This intermediate plays a crucial role in the development and production of Carvedilol, a medication used to treat heart failure, hypertension, and other cardiovascular conditions.

Check Digit Verification of cas no

The CAS Registry Mumber 1198090-71-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,9,8,0,9 and 0 respectively; the second part has 2 digits, 7 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1198090-71:
(9*1)+(8*1)+(7*9)+(6*8)+(5*0)+(4*9)+(3*0)+(2*7)+(1*1)=179
179 % 10 = 9
So 1198090-71-9 is a valid CAS Registry Number.

1198090-71-9Relevant academic research and scientific papers

Synthesis and characterization of potential impurities of carvedilol, an antihypertensive drug

Rao, Somisetti Narender,Sitaramaiah, Devarasetty,Srimannarayana, Kema,Rao, Challa Nageswar,Rao, Peddi Srinivasa,Babu, K. Sudhakar

experimental part, p. 85 - 93 (2011/03/19)

Carvedilol (Coreg) is a nonselective -adrenergic blocking agent with vasodilating activity. It is used for the treatment of congestive heart failure and hypertension. During the bulk synthesis of carvedilol, we have observed six impurities: Imp-I, Imp-II, Imp-III, Imp-IV, Imp-V, and Imp-VI. The present work describes the synthesis and characterization of these impurities. Copyright

Synthesis of impurity A in Carvedilol: a β-adrenergic receptor

Madhusudhan,Naidu,Kumar,Satyanarayana,Balraju

experimental part, p. 741 - 745 (2009/12/24)

Carvedilol is prepared by different synthetic approaches. Almost in all the approaches the major impurities that are known in the literature A, B, C, D and E are listed in European pharmacopoeia. The control of pharmaceutical impurities is currently a critical issue to the pharmaceutical industry. In this publication, a description of these impurities and their origins in Carvedilol process are presented along with the preparation of impurity A.

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