1198090-73-1

Basic information

• Product Name: N-2-Hydroxy-3-[[2-(Methoxyphenoxy)ethyl]aMine Carvedilol
• Synonyms: N-2-Hydroxy-3-[[2-(Methoxyphenoxy)ethyl]aMine Carvedilol;1-{{9-{2-Hydroxy-3-{[2-(2-methoxyphenoxy)ethyl]amino}propyl}-9H-carbazol-4-yl}oxy}-3-{[2-(2-methoxyphenoxy)ethyl]amino}-2-propanol;Carvedilol impurity A (PhEur);Carvedilol Related Compound A (USP);1-[4-[2-hydroxy-3-[2-(2-methoxyphenoxy)ethylamino]propoxy]carbazol-9-yl]-3-[2-(2-methoxyphenoxy)ethylamino]propan-2-ol;USP Carvedilol Related Impurity A
• CAS NO: 1198090-73-1
• Molecular Formula: C₃₆H₄₃N₃O₇
• Molecular Weight: 629.74252
• Product Categories: Aromatics, Heterocycles, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 1198090-73-1.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 828.3±65.0 °C(Predicted)
• Appearance: /
• Density: 1.22±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• Solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly, Heated, Sonicated)
• PKA: 13.90±0.20(Predicted)
• CAS DataBase Reference: N-2-Hydroxy-3-[[2-(Methoxyphenoxy)ethyl]aMine Carvedilol(CAS DataBase Reference)
• NIST Chemistry Reference: N-2-Hydroxy-3-[[2-(Methoxyphenoxy)ethyl]aMine Carvedilol(1198090-73-1)
• EPA Substance Registry System: N-2-Hydroxy-3-[[2-(Methoxyphenoxy)ethyl]aMine Carvedilol(1198090-73-1)

Safety Data

• Hazard Codes: Xi,N
• Statements: 43-50/53
• Safety Statements: 36/37-60-61
• WGK Germany: 3
• Hazardous Substances Data: 1198090-73-1(Hazardous Substances Data)

Usage

Uses

N-2-Hydroxy-3-[[2-(methoxyphenoxy)ethyl]amine Carvedilol (Carvedilol EP Impurity A) is an impurity from the process of Carvedilol (C184625).

Upstream product

• 1836-62-0 2-(2-methoxy-phenoxy)-ethylamine 
• 1198090-71-9 4-(oxiran-2-ylmethoxy)-9-(oxiran-2-ylmethyl)-9H-carbazole 
• 1198090-72-0 1-(benzyl(2-(2-methoxyphenoxy)ethyl)amino)-3-(4-(3-(benzyl(2-(2-methoxyphenoxy)ethyl)amino)-2-hydroxypropoxy)-9H-carbazol-9-yl)propan-2-ol 
• 51997-51-4 4-(2,3-epoxypropoxy)carbazole 
• 52602-39-8 9H-carbazol-4-ol 

Relevant articles and documents

Synthesis and characterization of potential impurities of carvedilol, an antihypertensive drug

Carvedilol (Coreg) is a nonselective -adrenergic blocking agent with vasodilating activity. It is used for the treatment of congestive heart failure and hypertension. During the bulk synthesis of carvedilol, we have observed six impurities: Imp-I, Imp-II, Imp-III, Imp-IV, Imp-V, and Imp-VI. The present work describes the synthesis and characterization of these impurities. Copyright